Artificial pancreas device systems for the closed-loop control of type 1 diabetes: what systems are in development?

S Trevitt, S Simpson, A Wood - Journal of diabetes science …, 2016 - journals.sagepub.com
Background: Closed-loop artificial pancreas device (APD) systems are externally worn
medical devices that are being developed to enable people with type 1 diabetes to regulate …

Technology in the management of type 1 diabetes mellitus—current status and future prospects

M Tauschmann, R Hovorka - Nature Reviews Endocrinology, 2018 - nature.com
Type 1 diabetes mellitus (T1DM) represents 5–10% of diabetes cases worldwide. The
incidence of T1DM is increasing, and there is no immediate prospect of a cure. As such …

[PDF][PDF] ISPAD clinical practice consensus guidelines 2018: diabetes technologies

JL Sherr, M Tauschmann, T Battelino, M de Bock… - Pediatr Diabetes, 2018 - bnsde.org
ISPAD Clinical Practice Consensus Guidelines 2018: Diabetes technologies Page 1 ISPAD
CLINICAL PRACTICE CONSENSUS GUIDELINES ISPAD Clinical Practice Consensus …

The UVA/Padova type 1 diabetes simulator goes from single meal to single day

R Visentin, E Campos-Náñez… - Journal of diabetes …, 2018 - journals.sagepub.com
Background: A new version of the UVA/Padova Type 1 Diabetes (T1D) Simulator is
presented which provides a more realistic testing scenario. The upgrades to the previous …

Periodic zone-MPC with asymmetric costs for outpatient-ready safety of an artificial pancreas to treat type 1 diabetes

R Gondhalekar, E Dassau, FJ Doyle III - Automatica, 2016 - Elsevier
Abstract A novel Model Predictive Control (MPC) law for an Artificial Pancreas (AP) to
automatically deliver insulin to people with type 1 diabetes is proposed. The MPC law is an …

Randomized crossover comparison of personalized MPC and PID control algorithms for the artificial pancreas

JE Pinsker, JB Lee, E Dassau, DE Seborg… - Diabetes …, 2016 - Am Diabetes Assoc
OBJECTIVE To evaluate two widely used control algorithms for an artificial pancreas (AP)
under nonideal but comparable clinical conditions. RESEARCH DESIGN AND METHODS …

Feasibility of long-term closed-loop control: a multicenter 6-month trial of 24/7 automated insulin delivery

B Kovatchev, P Cheng, SM Anderson… - Diabetes technology …, 2017 - liebertpub.com
Background: In the past few years, the artificial pancreas—the commonly accepted term for
closed-loop control (CLC) of blood glucose in diabetes—has become a hot topic in research …

Velocity-weighting & velocity-penalty MPC of an artificial pancreas: Improved safety & performance

R Gondhalekar, E Dassau, FJ Doyle III - Automatica, 2018 - Elsevier
Abstract A novel Model Predictive Control (MPC) law for the closed-loop operation of an
Artificial Pancreas (AP) to treat type 1 diabetes is proposed. The contribution of this paper is …

Adaptive zone model predictive control of artificial pancreas based on glucose-and velocity-dependent control penalties

D Shi, E Dassau, FJ Doyle - IEEE Transactions on Biomedical …, 2018 - ieeexplore.ieee.org
Objective: Zone model predictive control (MPC) has been proven to be an efficient approach
to closed-loop insulin delivery in clinical studies. In this paper, we aim to safely reduce mean …

Event-triggered model predictive control for embedded artificial pancreas systems

A Chakrabarty, S Zavitsanou, FJ Doyle… - IEEE Transactions on …, 2017 - ieeexplore.ieee.org
Objective: The development of artificial pancreas (AP) technology for deployment in low-
energy, embedded devices is contingent upon selecting an efficient control algorithm for …