Metalloenzymes catalyze a variety of reactions using a limited number of natural amino
acids and metallocofactors. Therefore, the environment beyond the primary coordination …

Enzymes are versatile and efficient biological catalysts that drive numerous cellular
processes, motivating the development of enzyme design approaches to tailor catalysts for …

Injectable biomimetic hydrogels have great potential for use in regenerative medicine as
cellular delivery vectors. However, they can suffer from issues relating to hypoxia, including …

While native CO2‐reducing enzymes display remarkable catalytic efficiency and product
selectivity, few artificial biocatalysts have been engineered to allow understanding how the …

Highlights•In-depth sequence analysis reveals that the protein fold universe is more
evolutionarily connected than previously assumed.•Short ancestral fragments are observed …

After the Devonian tetrapod land invasion, groups of terrestrial air-breathing and
endothermic mammals repeatedly went back to live in the sea, relying on air intake at the …

Rhodopsin, the light-sensitive visual pigment expressed in rod photoreceptors, is
specialized for vision in dim-light environments. Aquatic environments are particularly …

The continuously increasing level of atmospheric CO 2 in the atmosphere has led to global
warming. Converting CO 2 into other carbon compounds could mitigate its atmospheric …

Convergent adaptation to the same environment by multiple lineages frequently involves
rapid evolutionary change at the same genes, implicating these genes as important for …

Peptidylarginine deiminases (PADs) are a family of phylogenetically conserved calcium-
dependent enzymes which cause post-translational protein deimination. This can result in …