Activating killer cell immunoglobulin‐like receptors: detection, function and therapeutic use

MD Blunt, SI Khakoo - International Journal of Immunogenetics, 2020 - Wiley Online Library
Killer cell immunoglobulin‐like receptors (KIRs) have a central role in the control of natural
killer (NK) cell function. The functions of the activating KIRs, as compared to those of the …

Deciphering the killer‐cell immunoglobulin‐like receptor system at super‐resolution for natural killer and T‐cell biology

V Béziat, HG Hilton, PJ Norman, JA Traherne - Immunology, 2017 - Wiley Online Library
Killer‐cell immunoglobulin‐like receptors (KIR s) are components of two fundamental
biological systems essential for human health and survival. First, they contribute to host …

NK cell responses to cytomegalovirus infection lead to stable imprints in the human KIR repertoire and involve activating KIRs

V Béziat, LL Liu, JA Malmberg… - Blood, The Journal …, 2013 - ashpublications.org
Human natural killer (NK) cells are functionally regulated by killer cell immunoglobulin-like
receptors (KIRs) and their interactions with HLA class I molecules. As KIR expression in a …

Maternal activating KIRs protect against human reproductive failure mediated by fetal HLA-C2

SE Hiby, R Apps, AM Sharkey… - The Journal of …, 2010 - Am Soc Clin Investig
Many common disorders of pregnancy are attributed to insufficient invasion of the uterine
lining by trophoblast, fetal cells that are the major cell type of the placenta. Interactions …

Structural plasticity of KIR2DL2 and KIR2DL3 enables altered docking geometries atop HLA-C

S Moradi, S Stankovic, GM O'connor, P Pymm… - Nature …, 2021 - nature.com
The closely related inhibitory killer-cell immunoglobulin-like receptors (KIR), KIR2DL2 and
KIR2DL3, regulate the activation of natural killer cells (NK) by interacting with the human …

Large spectrum of HLA-C recognition by killer Ig–like receptor (KIR) 2DL2 and KIR2DL3 and restricted C1 specificity of KIR2DS2: dominant impact of KIR2DL2 …

G David, Z Djaoud, C Willem, N Legrand… - The Journal of …, 2013 - journals.aai.org
The interactions of killer Ig–like receptor 2D (KIR2D) with HLA-C ligands contribute to
functional NK cell education and regulate NK cell functions. Although simple alloreactive …

Activating killer cell Ig-like receptors in health and disease

MA Ivarsson, J Michaëlsson, C Fauriat - Frontiers in immunology, 2014 - frontiersin.org
Expression of non-rearranged HLA class I-binding receptors characterizes human and
mouse NK cells. The postulation of the missing-self hypothesis some 30 years ago triggered …

Activating KIRs and NKG2C in viral infections: toward NK cell memory?

M Della Chiesa, S Sivori, S Carlomagno… - Frontiers in …, 2015 - frontiersin.org
Natural killer (NK) cells are important players in the immune defense against viral infections.
The contribution of activating killer immunoglobulin-like receptors (KIRs) and CD94/NKG2C …

Immunological Aspects of Infertility—The Role of KIR Receptors and HLA-C Antigen

A Wasilewska, M Grabowska, D Moskalik-Kierat… - Cells, 2023 - mdpi.com
The mechanisms of immune tolerance of a mother against an antigenically foreign fetus
without a concomitant loss of defense capabilities against pathogens are the factors …

High-resolution genetic and phenotypic analysis of KIR2DL1 alleles and their association with pre-eclampsia

O Huhn, O Chazara, MA Ivarsson, C Retiere… - The Journal of …, 2018 - journals.aai.org
OH designed and executed experiments, analyzed data, and wrote the manuscript, OC
designed and executed experiments, analyzed data, and wrote the manuscript, MAI …