Gene regulation in time and space during X-chromosome inactivation
A Loda, S Collombet, E Heard - Nature Reviews Molecular Cell Biology, 2022 - nature.com
X-chromosome inactivation (XCI) is the epigenetic mechanism that ensures X-linked dosage
compensation between cells of females (XX karyotype) and males (XY). XCI is essential for …
compensation between cells of females (XX karyotype) and males (XY). XCI is essential for …
The diverse roles of DNA methylation in mammalian development and disease
MVC Greenberg, D Bourc'his - Nature reviews Molecular cell biology, 2019 - nature.com
DNA methylation is of paramount importance for mammalian embryonic development. DNA
methylation has numerous functions: it is implicated in the repression of transposons and …
methylation has numerous functions: it is implicated in the repression of transposons and …
The role of 3D genome organization in development and cell differentiation
In eukaryotes, the genome does not exist as a linear molecule but instead is hierarchically
packaged inside the nucleus. This complex genome organization includes multiscale …
packaged inside the nucleus. This complex genome organization includes multiscale …
Xist RNA in action: Past, present, and future
A Loda, E Heard - PLoS genetics, 2019 - journals.plos.org
In mammals, dosage compensation of sex chromosomal genes between females (XX) and
males (XY) is achieved through X-chromosome inactivation (XCI). The X-linked X-inactive …
males (XY) is achieved through X-chromosome inactivation (XCI). The X-linked X-inactive …
[HTML][HTML] Progress toward understanding chromosome silencing by Xist RNA
N Brockdorff, JS Bowness, G Wei - Genes & development, 2020 - genesdev.cshlp.org
The X inactive-specific transcript (Xist) gene is the master regulator of X chromosome
inactivation in mammals. Xist produces a long noncoding (lnc) RNA that accumulates over …
inactivation in mammals. Xist produces a long noncoding (lnc) RNA that accumulates over …
[HTML][HTML] X inactivation and escape: epigenetic and structural features
H Fang, CM Disteche, JB Berletch - Frontiers in cell and …, 2019 - frontiersin.org
X inactivation represents a complex multi-layer epigenetic mechanism that profoundly
modifies chromatin composition and structure of one X chromosome in females. The …
modifies chromatin composition and structure of one X chromosome in females. The …
[PDF][PDF] SFTSV infection induces BAK/BAX-dependent mitochondrial DNA release to trigger NLRP3 inflammasome activation
S Li, H Li, YL Zhang, QL Xin, ZQ Guan, X Chen… - Cell Reports, 2020 - cell.com
Severe fever with thrombocytopenia syndrome (SFTS) virus (SFTSV) is an emerging tick-
borne virus that carries a high fatality rate of 12%–50%. In-depth understanding of the …
borne virus that carries a high fatality rate of 12%–50%. In-depth understanding of the …
Epigenetic-sensitive pathways in personalized therapy of major cardiovascular diseases
The complex pathobiology underlying cardiovascular diseases (CVDs) has yet to be
explained. Aberrant epigenetic changes may result from alterations in enzymatic activities …
explained. Aberrant epigenetic changes may result from alterations in enzymatic activities …
XIST loss impairs mammary stem cell differentiation and increases tumorigenicity through Mediator hyperactivation
L Richart, ML Picod-Chedotel, M Wassef, M Macario… - Cell, 2022 - Elsevier
X inactivation (XCI) is triggered by upregulation of XIST, which coats the chromosome in cis,
promoting formation of a heterochromatic domain (Xi). XIST role beyond initiation of XCI is …
promoting formation of a heterochromatic domain (Xi). XIST role beyond initiation of XCI is …
Systematic allelic analysis defines the interplay of key pathways in X chromosome inactivation
Xist RNA, the master regulator of X chromosome inactivation, acts in cis to induce
chromosome-wide silencing. Whilst recent studies have defined candidate silencing factors …
chromosome-wide silencing. Whilst recent studies have defined candidate silencing factors …