Serine incorporator (SERINC) proteins, including five members 1-5, are carrier proteins that
incorporate the polar amino acid serine into membranes to facilitate the synthesis of …

The host proteins SERINC3 and SERINC5 are HIV-1 restriction factors that reduce infectivity
when incorporated into the viral envelope. The HIV-1 accessory protein Nef abrogates …

The evolutionary conflict between retroviruses and their vertebrate hosts over millions of
years has led to the emergence of cellular innate immune proteins termed restriction factors …

The SERINC (serine incorporator) proteins are host restriction factors that inhibit infection by
HIV through their incorporation into virions. Here, we found that SERINC3 and SERINC5 …

SERINC5 is a multipass intrinsic membrane protein that suppresses HIV-1 infectivity when
incorporated into budding virions. The HIV-1 Nef virulence factor prevents viral incorporation …

ABSTRACT A host cellular transmembrane protein, SERINC5, inhibits HIV-1 infectivity when
incorporated into progeny virions. Recent studies suggest that certain Envelope …

HIV-1 must counteract various host restrictions to establish productive infection. SERINC5 is
a potent restriction factor that blocks HIV-1 entry from virions, but its activity is counteracted …

Summary HIV-1-negative factor (Nef) protein antagonizes serine incorporator 5 (SERINC5)
by redirecting this potent restriction factor to the endosomes and lysosomes for degradation …

SERINC5 is a restriction factor that becomes incorporated into nascent retroviral particles,
impairing their ability to infect target cells. In turn, retroviruses have evolved …

The host transmembrane protein SERINC5 is incorporated into viral particles and restricts
infection by certain retroviruses. However, what motif of SERINC5 mediates this process …