Reactive oxygen species (ROS) are key signaling molecules that play an important role in
the progression of inflammatory disorders. An enhanced ROS generation by …

Obesity is associated with metabolic derangements in multiple tissues, which contribute to
the progression of insulin resistance and the metabolic syndrome. The underlying stimulus …

Chronic inflammation is a pathological condition characterized by continued active
inflammation response and tissue destruction. Many of the immune cells including …

The transcription factor NF-κB plays a major role in coordinating innate and adaptative
immunity, cellular proliferation, apoptosis and development. Since the discovery in 1991 that …

One of the adverse outcomes of acute inflammatory response is progressing to the chronic
stage or transforming into an aggressive process, which can develop rapidly and result in …

During normal cellular activities, various processes inside of cells produce reactive oxygen
species (ROS). Some of the most common ROS are hydrogen peroxide (H2O2), superoxide …

OBJECTIVE—Hyperglycemia-induced inflammation is central in diabetes complications,
and monocytes are important in orchestrating these effects. Toll-like receptors (TLRs) play a …

Despite the long held hypothesis that oxidant stress results in accumulated oxidative
damage to cellular macromolecules and subsequently to aging and age-related chronic …

S100A8 and S100A9 are cytoplasmic proteins expressed by phagocytes. High
concentrations of these proteins have been correlated with various inflammatory conditions …

Metabolic syndrome (MetS) is a complex pathophysiological state with incidence similar to
that of a global epidemic and represents a risk factor for the onset of chronic non …