Fragile X mental retardation protein (FMRP) is the product of the fragile X mental retardation
1 gene (FMR1), a gene that—when epigenetically inactivated by a triplet nucleotide repeat …

mRNA stability influences gene expression and translation in almost all living organisms,
and the levels of mRNA molecules in the cell are determined by a balance between …

Ribosome profiling suggests that ribosomes occupy many regions of the transcriptome
thought to be noncoding, including 5′ UTRs and long noncoding RNAs (lncRNAs) …

Maintaining proper mRNA levels is a key aspect in the regulation of gene expression. The
balance between mRNA synthesis and decay determines these levels. We demonstrate that …

Efficient and safe delivery of vulnerable mRNA is a long-standing challenge for the broad
application of the emerging mRNA-based therapeutics. Herein, a combinatorial library …

Messenger RNA-based vaccines have the potential to trigger robust cytotoxic immune
responses, which are essential for fighting cancer and infectious diseases like HIV. Dendritic …

Coronaviruses have brought severe challenges to public health all over the world in the past
20years. SARS-CoV-2, the causative agent of the COVID-19 pandemic that has led to …

mRNA is the central molecule of all forms of life. It is generally accepted that current life on
Earth descended from an RNA world. mRNA, after its first therapeutic description in 1992 …

Advances in genome editing technologies have enabled manipulation of genomes at the
single base level. These technologies are based on programmable nucleases (PNs) that …

MDM4 is a promising target for cancer therapy, as it is undetectable in most normal adult
tissues but often upregulated in cancer cells to dampen p53 tumor-suppressor function. The …