Constipation is a common functional gastrointestinal disorder, with prevalence in the
general population of approximately 20%. In the elderly population the incidence of …

Alterations in gut function with ageing have particular implications for oesophageal, gastric,
and colonic motility. Older individuals are particularly susceptible to malnutrition …

Accumulative indoxyl sulfate (IS) retained in chronic kidney disease (CKD) can potentiate
vascular endothelial dysfunction, and herein, we aim at elucidating the underlying …

A comprehensive genomic and proteomic, computational, and physiological approach was
employed to examine the (previously unexplored) role of microRNAs (miRNAs) as …

Background Oxidative stress is closely related to gut health. Exposures to oxidative stress in
one's diet and lifestyle can be evaluated by the oxidative balance score (OBS). However, the …

Intestinal barrier dysfunction is often observed clinically after spinal cord injury (SCI) and
seriously affects long-term quality of life. Hyperbaric oxygen (HBO) treatment has been …

In these studies, we developed a novel approach of in vivo magnetofection for localized
delivery of nucleic acids such as micro-RNA-139-5p (miR-139-5p; which is known to target …

Background and Aims Fecal incontinence (FI) is highly prevalent with substantial impacts on
quality of life and health care utilization. The impact of obesity on FI remains unclear, with …

Aging-associated decrease in internal anal sphincter (IAS) tone (AADI) is a major contributor
in the rectoanal incontinence (RI). To determine the pathogenesis of AADI, we investigated …

MicroRNAs (miRNAs) belong to a group of short noncoding RNA molecules with important
roles in cellular biology. miRNAs regulate gene expression by repressing translation or …