Permanent disabilities following CNS injuries result from the failure of injured axons to
regenerate and rebuild functional connections with their original targets. By contrast, injury …

Introduction Spinal cord injury (SCI) affects 25,000–50,000 people around the world each
year and there is no cure for SCI patients currently. The primary injury damages spinal cord …

Significance: The remarkable geometry of the axon exposes it to unique challenges for
survival and maintenance. Axonal degeneration is a feature of peripheral neuropathies …

Axons can be several orders of magnitude longer than neural somas, presenting logistical
difficulties in cargo trafficking and structural maintenance. Keeping the axon compartment …

Axonal regrowth is crucial for recovery from CNS injury but is severely restricted in adult
mammals. We used a genome-wide loss-of-function screen for factors limiting axonal …

Oxidative stress occurs at various phases of spinal cord injury (SCI), promoting detrimental
processes such as free radical injury of proteins, nucleic acids, lipids, cytoskeleton, and …

Accidents are the cause of some 50 deaths per 100,000 population each year; some 3% of
these are from traumatic spinal cord injury (SCI), a damage that causes temporary or …

Atr is a serine/threonine kinase, known to sense single-stranded DNA breaks and activate
the DNA damage checkpoint by phosphorylating Chek1, which inhibits Cdc25, causing cell …

Chemotherapy-induced peripheral neuropathy (CIPN) arises from collateral damage to
peripheral afferent sensory neurons by anticancer pharmacotherapy, leading to debilitating …

Abstract Poly (ADP‐ribose) polymerase 1 (PARP1) plays a fundamental role in DNA repair
and gene expression. Excessive PARP1 hyperactivation, however, has been associated …