Chemo-radiotherapy and systemic therapies have proven satisfactory outcomes as standard
treatments for various thoracic malignancies; however, adverse pulmonary effects, like …

BACKGROUND: Radiation pneumonitis is a dose-limiting toxicity for patients undergoing
concurrent chemoradiation therapy (CCRT) for non-small cell lung cancer (NSCLC). We …

Background Radiation-induced lung fibrosis (RILF) is a severe and life-threatening
complication of thoracic radiotherapy. Cell death is the key issue in RILF. Ferroptosis is a …

With the emergence of individualized medicine and the increasing amount and complexity of
available medical data, a growing need exists for the development of clinical decision …

Radiation-induced lung injury (RILI) is one of the most common and fatal complications of
thoracic radiotherapy, whereas no effective interventions are available. Andrographolide, an …

Purpose To assess the relationship between radiation dose and change in a set of
mathematical intensity-and texture-based features and to determine the ability of texture …

Purpose One of the major hurdles in enabling personalized medicine is obtaining sufficient
patient data to feed into predictive models. Combining data originating from multiple …

The phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of
rapamycin (mTOR)-dependent pathway is one of the most integral pathways linked to cell …

Radiation therapy is a major treatment modality for management of non-small cell lung
cancer. Radiation pneumonitis is a dose limiting toxicity of radiotherapy, affecting its …

Although radiotherapy improves locoregional control and survival in patients with non-small-
cell lung cancer, radiation pneumonitis is a common treatment-related toxicity. Many …