An essential step in renal function entails the formation of an ultrafiltrate that is delivered to
the renal tubules for subsequent processing. This process, known as glomerular filtration, is …

Almost all mammalian cell types have morphologies that are uniquely tailored to their
physiological functions. This immense variation in cell shape depends on an underlying …

Background Failure of the glomerular filtration barrier, primarily by loss of slit diaphragm
architecture, underlies nephrotic syndrome in minimal change disease. The etiology …

Focal segmental glomerulosclerosis (FSGS) is a glomerular disease characterized by
proteinuria, progression to end-stage renal disease, and recurrence of proteinuria after …

There are 4 classic features of nephrotic syndrome (Box 1). 1 There are many different
causes of nephrotic syndrome (Table 1), but they share a common pathophysiology …

Thirty to fifty percent of kidney transplant recipients have glomerular diseases as the
underlying causes of end-stage renal failure. While recurrence of glomerulonephritis is an …

Idiopathic nephrotic syndrome (INS) describes a group of pathologies of the renal
glomerulus that result in the classic triad of heavy proteinuria, oedema and …

Glucocorticoids are widely used in the treatment of human glomerular diseases, but their
mode of action is poorly understood particularly in steroid-sensitive nephrotic syndrome …

Hemopexin is an abundant plasma protein that effectively scavenges heme. When infused
into rats, hemopexin induces reversible proteinuria, and activated hemopexin is increased in …

In recent years there has been an explosion of interest in the glomerular podocyte, which
plays a central role in control of glomerular filtration. A host of new molecules have been …