Mitochondria are increasingly recognized as key players in genetic and acquired renal
diseases. Most mitochondrial cytopathies that cause renal symptoms are characterized by …

Mitochondria are well known as the centre of energy metabolism in eukaryotic cells.
However, they can not only generate ATP through the tricarboxylic acid cycle and oxidative …

Background This article explores the reasons in favour of revising and extending the current
14-day statutory limit to maintaining human embryos in culture. This limit is enshrined in law …

Chronic kidney disease (CKD) is a severe clinical syndrome with significant socioeconomic
impact worldwide. Orderly energy metabolism is essential for normal kidney function and …

This paper explores the ethics of introducing genome-editing technologies as a new
reproductive option. In particular, it focuses on whether genome editing can be considered a …

The distinction between germline and somatic gene editing is fundamental to the ethics of
human gene editing. Multiple conferences of scientists, ethicists, and policymakers, and …

Abstract Background Clustered Regularly Interspaced Short Palindromic Repeats-
associated (CRISPR-Cas) technology may allow for efficient and highly targeted gene …

In this paper, we argue that lesbian couples who wish to have children who are genetically
related to both of them should be allowed access to mitochondrial replacement techniques …

Abstract Purpose of Review The '14-day rule', which limits research on human embryos to
the first 14 days after fertilisation, has long been a pillar of regulation in this contested area …

Diminished ovarian reserve (DOR) is associated with a reduced quantity and quality of the
retrieved oocytes, usually leading to poor reproductive outcomes which remain a great …