Matrix metalloproteinase-9 (MMP-9) and its inhibitors in cancer: A minireview
Matrix metalloproteinases (MMPs) are zinc dependent proteolytic metalloenzyme. MMP-9 is
one of the most complex forms of matrix metalloproteinases. MMP-9 has the ability to …
one of the most complex forms of matrix metalloproteinases. MMP-9 has the ability to …
Inhibitors of gelatinases (MMP-2 and MMP-9) for the management of hematological malignancies
Abstract Matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) are
collectively known as gelatinases whereas MMP-2 is gelatinase-A and MMP-9 is termed as …
collectively known as gelatinases whereas MMP-2 is gelatinase-A and MMP-9 is termed as …
Pathological role of HDAC8: cancer and beyond
JY Kim, H Cho, J Yoo, GW Kim, YH Jeon, SW Lee… - Cells, 2022 - mdpi.com
Histone deacetylase 8 (HDAC8) is a class I HDAC that catalyzes the deacetylation of histone
and non-histone proteins. As one of the best-characterized isoforms, numerous studies have …
and non-histone proteins. As one of the best-characterized isoforms, numerous studies have …
Chemical-informatics approach to COVID-19 drug discovery: Monte Carlo based QSAR, virtual screening and molecular docking study of some in-house molecules …
Abstract World Health Organization characterized novel coronavirus disease (COVID-19),
caused by severe acute respiratory syndrome (SARS) coronavirus-2 (SARS-CoV-2) as …
caused by severe acute respiratory syndrome (SARS) coronavirus-2 (SARS-CoV-2) as …
Matrix metalloproteinases inhibitors in cancer treatment: an updated review (2013–2023)
Matrix metalloproteinases (MMPs) are identifiable members of proteolytic enzymes that can
degrade a wide range of proteins in the extracellular matrix (ECM). MMPs can be …
degrade a wide range of proteins in the extracellular matrix (ECM). MMPs can be …
Are inhibitors of histone deacetylase 8 (HDAC8) effective in hematological cancers especially acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL) …
Abstract Histone deacetylase 8 (HDAC8) aberrantly deacetylates histone and non-histone
proteins. These include structural maintenance of chromosome 3 (SMC3) cohesin protein …
proteins. These include structural maintenance of chromosome 3 (SMC3) cohesin protein …
Profiling the structural determinants of pyrrolidine derivative as gelatinases (MMP-2 and MMP-9) inhibitors using in silico approaches
Quantitative structure activity relationship (QSAR) studies on pyrrolidine derivatives have
been established using CoMFA, CoMSIA, and Hologram QSAR analysis to estimate the …
been established using CoMFA, CoMSIA, and Hologram QSAR analysis to estimate the …
Chimeric HDAC inhibitors: Comprehensive review on the HDAC‐based strategies developed to combat cancer
HM Hesham, DS Lasheen… - Medicinal Research …, 2018 - Wiley Online Library
Recently, molecular hybridization paradigm became an interesting and smart way to defeat
the multifaceted cancer disease by a single molecular entity that acts via several …
the multifaceted cancer disease by a single molecular entity that acts via several …
Selective inhibitors of medium-size S1′ pocket matrix metalloproteinases: a stepping stone of future drug discovery
Among various matrix metalloproteinases (MMPs), MMPs having medium-size S1′ pockets
are established as promising biomolecular targets for executing crucial roles in cancer …
are established as promising biomolecular targets for executing crucial roles in cancer …
Dual inhibitors of histone deacetylases and other cancer-related targets: A pharmacological perspective
Epigenetic enzymes histone deacetylases (HDACs) are clinically validated anticancer drug
targets which have been studied intensively in the past few decades. Although several drugs …
targets which have been studied intensively in the past few decades. Although several drugs …