DNA alkylation damage by nitrosamines and relevant DNA repair pathways

J Fahrer, M Christmann - International journal of molecular sciences, 2023 - mdpi.com
Nitrosamines occur widespread in food, drinking water, cosmetics, as well as tobacco smoke
and can arise endogenously. More recently, nitrosamines have been detected as impurities …

[HTML][HTML] Dysregulation of different modes of programmed cell death by epigenetic modifications and their role in cancer

R Damiescu, T Efferth, M Dawood - Cancer Letters, 2024 - Elsevier
Modifications of epigenetic factors affect our lives and can give important information
regarding one's state of health. In cancer, epigenetic modifications play a crucial role, as …

[HTML][HTML] Spatial and temporal mapping of neuron-microglia interaction modes in acute ischemic stroke

X Dou, W Ji, M Dai, S Sun, R Chen, J Yang… - Biochemical …, 2023 - Elsevier
Ischemic stroke (IS) is a major cause of morbidity and mortality worldwide, accounting for 75-
80% of all strokes. Under conditions of ischemia and hypoxia, neurons suffer damage or …

Molecular prognostic of nine parthanatos death‐related genes in glioma, particularly in COL8A1 identification

S Fan, H Li, K Liu - Journal of Neurochemistry, 2024 - Wiley Online Library
Post‐operative progression and chemotherapy resistance are the main causes of treatment
failure in glioma patients. There is a lack of ideal prediction models for post‐operative …

[HTML][HTML] Rapid evolution of genes with anti-cancer functions during the origins of large bodies and cancer resistance in elephants

J Bowman, VJ Lynch - bioRxiv, 2024 - ncbi.nlm.nih.gov
Elephants have emerged as a model system to study the evolution of body size and cancer
resistance because, despite their immense size, they have a very low prevalence of cancer …

Molecular mechanisms of cell death by parthanatos: More questions than answers

RD Moura, PD Mattos, PF Valente… - Genetics and Molecular …, 2024 - SciELO Brasil
Regulated cell death by a non-apoptotic pathway known as parthanatos is increasingly
recognised as a central player in pathological processes, including ischaemic tissue …

[HTML][HTML] Epi-Regulation of Cell Death in Cancer

A Beato, L Della Torre, V Capone… - Cell Death and …, 2022 - intechopen.com
How do organisms regulate the correct balance between the production of “new” cells and
the elimination of the “old” ones, remains an important biology issue under investigation …

PARP-1 improves leukemia outcomes by inducing parthanatos during chemotherapy

B Maru, A Messikommer, L Huang, K Seipel… - Cell Reports …, 2023 - cell.com
Previous chemotherapy research has focused almost exclusively on apoptosis. Here, a
standard frontline drug combination of cytarabine and idarubicin induces distinct features of …