CaMKII: a central molecular organizer of synaptic plasticity, learning and memory
Abstract Calcium–calmodulin (CaM)-dependent protein kinase II (CaMKII) is the most
abundant protein in excitatory synapses and is central to synaptic plasticity, learning and …
abundant protein in excitatory synapses and is central to synaptic plasticity, learning and …
[HTML][HTML] Molecular mechanisms of ischemia and glutamate excitotoxicity
Excitotoxicity is classically defined as the neuronal damage caused by the excessive
release of glutamate, and subsequent activation of excitatory plasma membrane receptors …
release of glutamate, and subsequent activation of excitatory plasma membrane receptors …
Therapeutic potential of N-methyl-D-aspartate receptor modulators in psychiatry
Abstract N-methyl-D-aspartate (NMDA) receptors mediate a slow component of excitatory
synaptic transmission, are widely distributed throughout the central nervous system, and …
synaptic transmission, are widely distributed throughout the central nervous system, and …
Trafficking of NMDA receptors is essential for hippocampal synaptic plasticity and memory consolidation
X Yang, R Gong, L Qin, Y Bao, Y Fu, S Gao, H Yang… - Cell Reports, 2022 - cell.com
NMDA receptor (NMDAR) plays a vital role in brain development and normal physiological
functions. Surface trafficking of NMDAR contributes to the modulation of synaptic functions …
functions. Surface trafficking of NMDAR contributes to the modulation of synaptic functions …
A frameshift variant of GluN2A identified in an epilepsy patient results in NMDA receptor mistargeting
N-methyl-d-aspartate receptors (NMDARs) are crucial for neuronal development and
synaptic plasticity. Dysfunction of NMDARs is associated with multiple neurodevelopmental …
synaptic plasticity. Dysfunction of NMDARs is associated with multiple neurodevelopmental …
Microglial TNFα orchestrates protein phosphorylation in the cortex during the sleep period and controls homeostatic sleep
Sleep intensity is adjusted by the length of previous awake time, and under tight homeostatic
control by protein phosphorylation. Here, we establish microglia as a new cellular …
control by protein phosphorylation. Here, we establish microglia as a new cellular …
The role of zinc and NMDA receptors in autism spectrum disorders
NMDA-type glutamate receptors are critical for synaptic plasticity in the central nervous
system. Their unique properties and age-dependent arrangement of subunit types underpin …
system. Their unique properties and age-dependent arrangement of subunit types underpin …
c-Abl kinase at the crossroads of healthy synaptic remodeling and synaptic dysfunction in neurodegenerative diseases
DA Gutiérrez, A Chandía-Cristi, MJ Yáñez… - Neural Regeneration …, 2023 - journals.lww.com
Our ability to learn and remember depends on the active formation, remodeling, and
elimination of synapses. Thus, the development and growth of synapses as well as their …
elimination of synapses. Thus, the development and growth of synapses as well as their …
NMDA receptor C-terminal domain signalling in development, maturity, and disease
K Haddow, PC Kind, GE Hardingham - International Journal of Molecular …, 2022 - mdpi.com
The NMDA receptor is a Ca2+-permeant glutamate receptor which plays key roles in health
and disease. Canonical NMDARs contain two GluN2 subunits, of which 2A and 2B are …
and disease. Canonical NMDARs contain two GluN2 subunits, of which 2A and 2B are …
Regulation of the NMDA receptor by its cytoplasmic domains:(How) is the tail wagging the dog?
Y Ishchenko, MG Carrizales, AJ Koleske - Neuropharmacology, 2021 - Elsevier
Excitatory neurotransmission mediated by N-methyl-d-aspartate receptors (NMDARs) is
critical for synapse development, function, and plasticity in the brain. NMDARs are tetra …
critical for synapse development, function, and plasticity in the brain. NMDARs are tetra …