Runs of homozygosity: current knowledge and applications in livestock
E Peripolli, DP Munari, M Silva, ALF Lima… - Animal …, 2017 - Wiley Online Library
This review presents a broader approach to the implementation and study of runs of
homozygosity (ROH) in animal populations, focusing on identifying and characterizing ROH …
homozygosity (ROH) in animal populations, focusing on identifying and characterizing ROH …
[HTML][HTML] Symposium review: The genomic architecture of inbreeding: How homozygosity affects health and performance
Inbreeding depression is a growing concern in livestock because it can detrimentally affect
animal fitness, health, and production levels. Genomic information can be used to more …
animal fitness, health, and production levels. Genomic information can be used to more …
Inbreeding and runs of homozygosity: A possible solution to an old problem
Quantifying human, plant and livestock inbreeding has been an important goal of
evolutionary biologists and agricultural scientists for nearly a century, and methods to do so …
evolutionary biologists and agricultural scientists for nearly a century, and methods to do so …
Analysis of runs of homozygosity and their relationship with inbreeding in five cattle breeds farmed in Italy
Increased inbreeding is an inevitable consequence of selection in livestock populations. The
analysis of high‐density single nucleotide polymorphisms (SNPs) facilitates the identification …
analysis of high‐density single nucleotide polymorphisms (SNPs) facilitates the identification …
Detect runs of homozygosity and runs of heterozygosity in diploid genomes
detectRUNS is a R package for the detection of runs of homozygosity (ROH/ROHom) and of
heterozygosity (ROHet, aka “heterozygosity-rich regions”) in diploid genomes. ROH/ROHom …
heterozygosity (ROHet, aka “heterozygosity-rich regions”) in diploid genomes. ROH/ROHom …
Estimating autozygosity from high-throughput information: effects of SNP density and genotyping errors
Background Runs of homozygosity are long, uninterrupted stretches of homozygous
genotypes that enable reliable estimation of levels of inbreeding (ie, autozygosity) based on …
genotypes that enable reliable estimation of levels of inbreeding (ie, autozygosity) based on …
[HTML][HTML] Evaluation of inbreeding depression in Holstein cattle using whole-genome SNP markers and alternative measures of genomic inbreeding
The effects of increased pedigree inbreeding in dairy cattle populations have been well
documented and result in a negative impact on profitability. Recent advances in genotyping …
documented and result in a negative impact on profitability. Recent advances in genotyping …
Estimates of autozygosity derived from runs of homozygosity: empirical evidence from selected cattle populations
Using genome‐wide SNP data, we calculated genomic inbreeding coefficients (FROH> 1
Mb, FROH> 2 Mb, FROH> 8 Mb and FROH> 16 Mb) derived from runs of homozygosity …
Mb, FROH> 2 Mb, FROH> 8 Mb and FROH> 16 Mb) derived from runs of homozygosity …
Assessment of runs of homozygosity islands and estimates of genomic inbreeding in Gyr (Bos indicus) dairy cattle
E Peripolli, NB Stafuzza, DP Munari, ALF Lima… - BMC genomics, 2018 - Springer
Background Runs of homozygosity (ROH) are continuous homozygous segments of the
DNA sequence. They have been applied to quantify individual autozygosity and used as a …
DNA sequence. They have been applied to quantify individual autozygosity and used as a …
Genome-wide characterization of selection signatures and runs of homozygosity in Ugandan goat breeds
Both natural and artificial selection are among the main driving forces shaping genetic
variation across the genome of livestock species. Selection typically leaves signatures in the …
variation across the genome of livestock species. Selection typically leaves signatures in the …