Neurobiology of glycine transporters: From molecules to behavior

BL Marques, OC Oliveira-Lima, GA Carvalho… - Neuroscience & …, 2020 - Elsevier
Abstract Glycine transporters (GlyTs) are Na+/Cl−-dependent neurotransmitter transporters,
responsible for l-glycine uptake into the central nervous system. GlyTs are members of the …

Is there a glutathione centered redox dysregulation subtype of schizophrenia?

L Palaniyappan, MTM Park, P Jeon, R Limongi, K Yang… - Antioxidants, 2021 - mdpi.com
Schizophrenia continues to be an illness with poor outcome. Most mechanistic changes
occur many years before the first episode of schizophrenia; these are not reversible after the …

In Vitro and In Vivo Neuroprotective Effects of Sarcosine

A Tanas, ÖÖ Tozlu, T Gezmiş… - BioMed research …, 2022 - Wiley Online Library
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by behavioral and
psychological symptoms in addition to cognitive impairment and loss of memory. The exact …

Sarcosine (glycine transporter inhibitor) attenuates behavioural and biochemical changes induced by ketamine, in the rat model of schizophrenia

A Kumar, A Akhtar, A Kuhad, SP Sah - Experimental Brain Research, 2023 - Springer
Schizophrenia is a neurological disorder that alters the behavior and affects the quality of life
of a patient. It is characterized by hallucinations, disorganized behavior, cognitive …

NMR-based metabonomics and correlation analysis reveal potential biomarkers associated with chronic atrophic gastritis

J Cui, Y Liu, Y Hu, J Tong, A Li, T Qu, X Qin… - Journal of Pharmaceutical …, 2017 - Elsevier
Chronic atrophic gastritis (CAG) is one of the most important pre-cancerous states with a
high prevalence. Exploring of the underlying mechanism and potential biomarkers is of …

Design, synthesis and biological evaluation of diosgenin-amino acid derivatives with dual functions of neuroprotection and angiogenesis

D Cai, J Qi, Y Yang, W Zhang, F Zhou, X Jia, W Guo… - Molecules, 2019 - mdpi.com
Diosgenin, a natural product with steroidal structure, has a wide range of clinical
applications in China. It also shows great potential in the treatment of blood clots and nerve …

Effects of blast overpressure on neurons and glial cells in rat organotypic hippocampal slice cultures

AP Miller, AS Shah, BV Aperi, MD Budde… - Frontiers in …, 2015 - frontiersin.org
Due to recent involvement in military conflicts, and an increase in the use of explosives,
there has been an escalation in the incidence of blast-induced traumatic brain injury (bTBI) …

GlyT1 Inhibition by NFPS Promotes Neuroprotection in Amyloid-β-Induced Alzheimer's Disease Animal Model

OC Oliveira-Lima, GA de Carvalho… - Neurochemical …, 2024 - Springer
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the
accumulation of amyloid-β, leading to N-methyl-D-aspartate (NMDA) receptor-dependent …

Glycine transporters type 1 inhibitor promotes brain preconditioning against NMDA-induced excitotoxicity

MCX Pinto, IV de Assis Lima, FLP da Costa, DV Rosa… - …, 2015 - Elsevier
Brain preconditioning is a protective mechanism, which can be activated by sub-lethal
stimulation of the NMDA receptors (NMDAR) and be used to achieve neuroprotection …

Neuroprotection mediated by remote preconditioning is associated with a decrease in systemic oxidative stress and changes in brain and blood glutamate …

J Jachova, M Gottlieb, M Nemethova… - Neurochemistry …, 2019 - Elsevier
It has been shown that ischemia of remote organs can generate resistance to ischemic
conditions within sensitive brain tissues. However, only limited information about its …