Neurodegenerative diseases are a common cause of morbidity and cognitive impairment in
older adults. Most clinicians who care for the elderly are not trained to diagnose these …

Alzheimer's disease (AD) is considered a polygenic disorder. This view is clouded, however,
by lingering uncertainty over how to treat the quasi" monogenic" role of apolipoprotein E …

A positron emission tomography (PET) tracer detecting α-synuclein pathology will improve
the diagnosis, and ultimately the treatment of α-synuclein-related diseases. Here we show …

Alzheimer's disease and related dementias lack effective treatment or cures and are major
public health challenges. Risk for Alzheimer's disease and related dementias is partially …

Possession of the ε4 allele of apolipoprotein E (APOE) is the primary genetic risk factor for
the sporadic form of Alzheimer's disease (AD). While researchers have extensively …

The risk of Alzheimer disease (AD) increases with age, family history and informative genetic
variants. Sadly, there is still no cure or means of prevention. As in other complex diseases …

Pathologies that are causative for neurodegenerative disease (ND) are also frequently
present in unimpaired, older individuals. In this retrospective study of 1647 autopsied …

Cerebral amyloid angiopathy (CAA), limbic-predominant age-related TDP-43
encephalopathy neuropathological change (LATE-NC) and Lewy bodies occur in the …

Alzheimer's disease (AD) and Parkinson's disease (PD) are the most common
neurodegenerative diseases (NDs), presenting a broad range of symptoms from motor …

Objective Our objectives were to characterize the inter‐relation of known dementia‐related
neuropathologies in one comprehensive model and quantify the extent to which …