c-Jun N-terminal kinases (JNKs), first characterized as stress-activated members of the
mitogen-activated protein kinase (MAPK) family, have become a focus of inhibitor screening …

The c-Jun-NH 2-terminal kinase (JNK) signaling pathway plays a critical role in regulating
cell fate, being implicated in a multitude of diseases ranging from cancer to neurological and …

Apoptosis is associated with virus-induced human diseases of the central nervous system,
heart and liver, and causes substantial morbidity and mortality. Although virus-induced …

Secretion of Amyloid-beta peptide (Aβ) circulating oligomers and their aggregate forms
derived by processing of beta-amyloid precursor protein (APP) are a key event in …

The c-Jun N-terminal kinases (JNKs) have been the subject of intense interest since their
discovery in the early 1990s. Major research programs have been directed to the screening …

Virus-induced apoptosis is thought to be the primary mechanism of cell death following
reovirus infection. Induction of cell death following reovirus infection is initiated by the …

Abstract c-Jun N-terminal kinases (JNKs) and in particular JNK3 the neuronal specific
isoform, have been recognized as important enzymes in the pathology of diverse …

Apoptosis plays an important role in the pathogenesis of reovirus encephalitis and
myocarditis in infected animals. Differences in apoptosis efficiency displayed by reovirus …

The rise in type 1 diabetes (T1D) incidence in recent decades is probably related to
modifications in environmental factors. Viruses are among the putative environmental …

Apoptosis plays an important role in the pathogenesis of reovirus encephalitis. Reovirus
outer-capsid protein μ1, which functions to penetrate host cell membranes during viral entry …