▪ Abstract Several members of the tumor necrosis factor receptor (TNFR) family function after
initial T cell activation to sustain T cell responses. This review focuses on CD27, 4-1BB …

Immunotherapy using autologous T cells has emerged to be a powerful treatment option for
patients with metastatic melanoma. These include the adoptive transfer of autologous tumor …

To enhance the strength of activation afforded by tumor antigen-specific receptors, we
investigated the effect of adding combined CD28 and 4-1BB costimulatory signaling …

4-1BB is a major costimulatory receptor that promotes the survival and expansion of
activated T cells. Administration of agonistic anti–4-1BB Abs has been previously shown to …

The activation of T cells plays a central role in antitumor immunity. In order to activate naïve
T cells, two key signals are required. Signal one is provided through the T-cell receptor …

The CD28-B7 and CD154-CD40 pathways have been described as the critical costimulatory
pathways for T cell activation. Blockade of these pathways has been reported to regulate …

Abstract Anti-4-1BB monoclonal antibody (mAb) has been shown to induce antitumor
immunity by a CD4/CD8-dependent mechanism, but its direct effect on tumor-specific CD8+ …

Purpose: Eradication of post-treatment residual myeloma cells is needed to prevent
relapses, and immunostimulatory monoclonal antibodies (mAb) such as anti-CD137, CTLA …

Renal cell carcinoma (RCC), one of the most incurable malignancies, is highly resistant to
chemotherapy and radiotherapy. Cytokine immunotherapy has been the standard approach …

Immune regulation has been shown to be involved in the progressive growth of some
murine tumours. Interruption of immune regulatory pathways via activation of 4‐1BB or …