Genetic and epigenetic changes in DNA are involved in cancer development and tumor
progression. Histone deacetylases (HDACs) are key regulators of gene expression that act …

The repair of DNA damage is a complex process that relies on particular pathways to
remedy specific types of damage to DNA. The range of insults to DNA includes small …

Cancer-specific inhibitors that reflect the unique metabolic needs of cancer cells are rare.
Here we describe Gboxin, a small molecule that specifically inhibits the growth of primary …

DNA double-strand breaks (DSBs) are deleterious DNA lesions that if left unrepaired or are
misrepaired, potentially result in chromosomal aberrations, known drivers of carcinogenesis …

Radiation-induced high-grade gliomas (RIGs) are an incurable late complication of cranial
radiation therapy. We performed DNA methylation profiling, RNA-seq, and DNA sequencing …

DNA replication is a highly demanding process regarding the energy and material supply
and must be precisely regulated, involving multiple cellular feedbacks. The slowing down or …

Upon the induction of DNA damage, the chromatin structure unwinds to allow access to
enzymes to catalyse the repair. The regulation of the winding and unwinding of chromatin …

PRMT5 participates in various cellular processes, including transcription regulation, signal
transduction, mRNA splicing, and DNA repair; however, its mechanism of regulation is …

Chemoresistance is one of the leading causes of mortality in breast cancer (BC).
Understanding the molecules regulating chemoresistance is critical in order to combat …

Utilization of thermal therapy (hyperthermia) is defined as the application of exogenous heat
induction and represents a concept that is far from new as it goes back to ancient times …