An overview of process systems engineering approaches for process intensification: State of the art
Process intensification offers the potential to drastically reduce the energy consumption and
cost of producing chemicals from both bulk and distributed feedstocks. This review article …
cost of producing chemicals from both bulk and distributed feedstocks. This review article …
A review on the modernization of pharmaceutical development and manufacturing–Trends, perspectives, and the role of mathematical modeling
Recently, the pharmaceutical industry has been facing several challenges associated to the
use of outdated development and manufacturing technologies. The return on investment on …
use of outdated development and manufacturing technologies. The return on investment on …
[HTML][HTML] Process intensification
FJ Keil - Reviews in Chemical Engineering, 2018 - degruyter.com
Process intensification (PI) is a rapidly growing field of research and industrial development
that has already created many innovations in chemical process industry. PI is directed …
that has already created many innovations in chemical process industry. PI is directed …
[HTML][HTML] Bioprocess control: current progress and future perspectives
Typical bioprocess comprises of different unit operations wherein a near optimal
environment is required for cells to grow, divide, and synthesize the desired product …
environment is required for cells to grow, divide, and synthesize the desired product …
The current scientific and regulatory landscape in advancing integrated continuous biopharmaceutical manufacturing
AC Fisher, MH Kamga, C Agarabi, K Brorson… - Trends in …, 2019 - cell.com
There is a trend across the pharmaceutical sector toward process intensification and
continuous manufacturing to produce small-molecule drugs or biotechnology products. For …
continuous manufacturing to produce small-molecule drugs or biotechnology products. For …
[HTML][HTML] A critical review of recent trends, and a future perspective of optical spectroscopy as PAT in biopharmaceutical downstream processing
As competition in the biopharmaceutical market gets keener due to the market entry of
biosimilars, process analytical technologies (PATs) play an important role for process …
biosimilars, process analytical technologies (PATs) play an important role for process …
Recent advances in integrated process analytical techniques, modeling, and control strategies to enable continuous biomanufacturing of monoclonal antibodies
V Chopda, A Gyorgypal, O Yang… - Journal of Chemical …, 2022 - Wiley Online Library
Continuous bioprocessing is significantly changing the biological drugs (or biologics)
manufacturing landscape by potentially improving product quality, process stability, and …
manufacturing landscape by potentially improving product quality, process stability, and …
Continuous integrated manufacturing for biopharmaceuticals: A new paradigm or an empty promise?
Continuous integrated bioprocessing has elicited considerable interest from the biopharma
industry for the many purported benefits it promises. Today many major biopharma …
industry for the many purported benefits it promises. Today many major biopharma …
Challenges in process control for continuous processing for production of monoclonal antibody products
Continuous processing has been garnering much interest lately for production of
biopharmaceutical products. Purported benefits include higher productivity (10-15X) …
biopharmaceutical products. Purported benefits include higher productivity (10-15X) …
Modern trends in downstream processing of biotherapeutics through continuous chromatography: The potential of Multicolumn Countercurrent Solvent Gradient …
C De Luca, S Felletti, G Lievore, T Chenet… - TrAC Trends in …, 2020 - Elsevier
Single-column (batch) preparative chromatography is the technique of choice for purification
of biotherapeutics but it is often characterized by an intrinsic limitation in terms of yield-purity …
of biotherapeutics but it is often characterized by an intrinsic limitation in terms of yield-purity …