An overview of process systems engineering approaches for process intensification: State of the art

Y Tian, SE Demirel, MMF Hasan… - … and Processing-Process …, 2018 - Elsevier
Process intensification offers the potential to drastically reduce the energy consumption and
cost of producing chemicals from both bulk and distributed feedstocks. This review article …

A review on the modernization of pharmaceutical development and manufacturing–Trends, perspectives, and the role of mathematical modeling

F Destro, M Barolo - International Journal of Pharmaceutics, 2022 - Elsevier
Recently, the pharmaceutical industry has been facing several challenges associated to the
use of outdated development and manufacturing technologies. The return on investment on …

[HTML][HTML] Process intensification

FJ Keil - Reviews in Chemical Engineering, 2018 - degruyter.com
Process intensification (PI) is a rapidly growing field of research and industrial development
that has already created many innovations in chemical process industry. PI is directed …

[HTML][HTML] Bioprocess control: current progress and future perspectives

AS Rathore, S Mishra, S Nikita, P Priyanka - Life, 2021 - mdpi.com
Typical bioprocess comprises of different unit operations wherein a near optimal
environment is required for cells to grow, divide, and synthesize the desired product …

The current scientific and regulatory landscape in advancing integrated continuous biopharmaceutical manufacturing

AC Fisher, MH Kamga, C Agarabi, K Brorson… - Trends in …, 2019 - cell.com
There is a trend across the pharmaceutical sector toward process intensification and
continuous manufacturing to produce small-molecule drugs or biotechnology products. For …

[HTML][HTML] A critical review of recent trends, and a future perspective of optical spectroscopy as PAT in biopharmaceutical downstream processing

L Rolinger, M Ruedt, J Hubbuch - Analytical and bioanalytical chemistry, 2020 - Springer
As competition in the biopharmaceutical market gets keener due to the market entry of
biosimilars, process analytical technologies (PATs) play an important role for process …

Recent advances in integrated process analytical techniques, modeling, and control strategies to enable continuous biomanufacturing of monoclonal antibodies

V Chopda, A Gyorgypal, O Yang… - Journal of Chemical …, 2022 - Wiley Online Library
Continuous bioprocessing is significantly changing the biological drugs (or biologics)
manufacturing landscape by potentially improving product quality, process stability, and …

Continuous integrated manufacturing for biopharmaceuticals: A new paradigm or an empty promise?

AS Rathore, G Thakur, N Kateja - Biotechnology and …, 2023 - Wiley Online Library
Continuous integrated bioprocessing has elicited considerable interest from the biopharma
industry for the many purported benefits it promises. Today many major biopharma …

Challenges in process control for continuous processing for production of monoclonal antibody products

AS Rathore, S Nikita, G Thakur, N Deore - Current Opinion in Chemical …, 2021 - Elsevier
Continuous processing has been garnering much interest lately for production of
biopharmaceutical products. Purported benefits include higher productivity (10-15X) …

Modern trends in downstream processing of biotherapeutics through continuous chromatography: The potential of Multicolumn Countercurrent Solvent Gradient …

C De Luca, S Felletti, G Lievore, T Chenet… - TrAC Trends in …, 2020 - Elsevier
Single-column (batch) preparative chromatography is the technique of choice for purification
of biotherapeutics but it is often characterized by an intrinsic limitation in terms of yield-purity …