Cisplatin and other platinum-based drugs, such as carboplatin, ormaplatin, and oxaliplatin,
have been widely used to treat a multitude of human cancers. However, a considerable …

Cisplatin, cisplatinum, or cis-diamminedichloroplatinum (II), is a well-known
chemotherapeutic drug. It has been used for treatment of numerous human cancers …

Evidence of significant hearing loss during the early days of use of cisplatin as a
chemotherapeutic agent in cancer patients has stimulated research into the causes and …

Poly (ADP-ribose) polymerase 1 (PARP1) is a nuclear protein that is activated by binding to
DNA lesions and catalyzes poly (ADP-ribosyl) ation of nuclear acceptor proteins, including …

Programmed cell death contributes to host defense against pathogens. To investigate the
relative importance of pyroptosis, necroptosis, and apoptosis during Salmonella infection …

Mitochondria play key roles in activating apoptosis in mammalian cells. Bcl-2 family
members regulate the release of proteins from the space between the mitochondrial inner …

We report here that BID, a BH3 domain–containing proapoptotic Bcl2 family member, is a
specific proximal substrate of Casp8 in the Fas apoptotic signaling pathway. While full …

Baicalin has been widely investigated against different types of malignancies both at the
cellular and molecular levels over the past few years. Due to its remarkable anti-proliferative …

The metastatic process is highly inefficient—very few of the many cells that migrate from the
primary tumour successfully colonize distant sites. One proposed mechanism to explain this …

We report here the purification of a cytosolic protein that induces cytochrome c release from
mitochondria in response to caspase-8, the apical caspase activated by cell surface death …