The world population is ageing rapidly. As society ages, the incidence of physical limitations
is dramatically increasing, which reduces the quality of life and increases healthcare …

Critical illness polyneuropathies (CIP) and myopathies (CIM) are common complications of
critical illness. Several weakness syndromes are summarized under the term intensive care …

The complexity of human DNA has been affected by aerobic metabolism, including
endurance exercise and oxygen toxicity. Aerobic endurance exercise could play an …

Prolonged periods of skeletal muscle inactivity or mechanical unloading (bed rest, hindlimb
unloading, immobilization, spaceflight and reduced step) can result in a significant loss of …

Aim We investigated architectural, functional and molecular responses of human skeletal
muscle to concentric (CON) or eccentric (ECC) resistance training (RT). Methods Twelve …

Key points• The branched‐chain amino acid (BCAA) leucine acts as both a 'trigger'for the
initiation of protein synthesis, and as a substrate for newly synthesized protein.• As a BCAA …

Sarcopenia reflects a progressive withdrawal of anabolism and an increased catabolism,
along with a reduced muscle regeneration capacity. Muscle force and power decline more …

Situations such as the recovery from injury and illness can lead to enforced periods of
muscle disuse or unloading. Such circumstances lead to rapid skeletal muscle atrophy, loss …

Aim The impact of disuse on the loss of skeletal muscle mass and strength has been well
documented. Given that most studies have investigated muscle atrophy after more than 2 …

Prolonged immobility is harmful with rapid reductions in muscle mass, bone mineral density
and impairment in other body systems evident within the first week of bed rest which is …