The secret life of conjugative relaxases

DL Guzmán-Herrador, M Llosa - Plasmid, 2019 - Elsevier
Conjugative relaxases are well-characterized proteins responsible for the site-and strand-
specific endonucleolytic cleavage and strand transfer reactions taking place at the start and …

Conjugative Coupling Proteins and the Role of Their Domains in Conjugation, Secondary Structure and in vivo Subcellular Location

I Álvarez-Rodríguez, B Ugarte-Uribe… - Frontiers in Molecular …, 2020 - frontiersin.org
Type IV Coupling Proteins (T4CPs) are essential elements in many type IV secretion
systems (T4SSs). The members of this family display sequence, length, and domain …

Bacterial injection machines: Evolutionary diverse but functionally convergent

S Bleves, JE Galán, M Llosa - 2020 - Wiley Online Library
Many human pathogens use Type III, Type IV, and Type VI secretion systems to deliver
effectors into their target cells. The contribution of these secretion systems to microbial …

In vivo delivery of functional Cas: DNA nucleoprotein complexes into recipient bacteria through a Type IV Secretion System

DL Guzman-Herrador, A Fernandez-Gomez… - bioRxiv, 2024 - biorxiv.org
CRISPR-associated (Cas) endonucleases and their derivatives are widespread tools for the
targeted genetic modification of both prokaryotic and eukaryotic genomes. A critical step of …

Study of the role transmembrane domain of Type IV Coupling Proteins

I Alvarez Rodriguez - 2020 - research.science.eus
La conjugación bacteriana es el mecanismo más importante en la diseminación de genes
de resistencia a antibióticos entre bacterias. Este proceso se realiza mediante unos …