A compendium of mutational cancer driver genes
A fundamental goal in cancer research is to understand the mechanisms of cell
transformation. This is key to developing more efficient cancer detection methods and …
transformation. This is key to developing more efficient cancer detection methods and …
Multiplex assessment of protein variant abundance by massively parallel sequencing
KA Matreyek, LM Starita, JJ Stephany, B Martin… - Nature …, 2018 - nature.com
Determining the pathogenicity of genetic variants is a critical challenge, and functional
assessment is often the only option. Experimentally characterizing millions of possible …
assessment is often the only option. Experimentally characterizing millions of possible …
Structural mechanisms of PTEN regulation
GR Masson, RL Williams - Cold Spring …, 2020 - perspectivesinmedicine.cshlp.org
The tumor suppressor phosphatase and tensin homolog on chromosome 10 (PTEN) is a
tightly regulated enzyme responsible for dephosphorylating the progrowth lipid messenger …
tightly regulated enzyme responsible for dephosphorylating the progrowth lipid messenger …
Systematic functional interrogation of rare cancer variants identifies oncogenic alleles
Cancer genome characterization efforts now provide an initial view of the somatic alterations
in primary tumors. However, most point mutations occur at low frequency, and the function of …
in primary tumors. However, most point mutations occur at low frequency, and the function of …
Characterization of PTEN mutations in brain cancer reveals that pten mono-ubiquitination promotes protein stability and nuclear localization
JRM Yang, P Schiapparelli, HN Nguyen, A Igarashi… - Oncogene, 2017 - nature.com
PTEN is a PIP3 phosphatase that antagonizes oncogenic PI3-kinase signalling. Due to its
critical role in suppressing the potent signalling pathway, it is one of the most mutated …
critical role in suppressing the potent signalling pathway, it is one of the most mutated …
[HTML][HTML] Inherited PTEN mutations and the prediction of phenotype
NR Leslie, M Longy - Seminars in cell & developmental biology, 2016 - Elsevier
PTEN has been heavily studied due to its role as a tumour suppressor and as a core
inhibitory component of the phosphoinositide 3-kinase (PI3K) signalling network. It is a …
inhibitory component of the phosphoinositide 3-kinase (PI3K) signalling network. It is a …
The mechanism of full activation of tumor suppressor PTEN at the phosphoinositide-enriched membrane
H Jang, IN Smith, C Eng, R Nussinov - Iscience, 2021 - cell.com
Tumor suppressor PTEN, the second most highly mutated protein in cancer,
dephosphorylates signaling lipid PIP 3 produced by PI3Ks. Excess PIP 3 promotes cell …
dephosphorylates signaling lipid PIP 3 produced by PI3Ks. Excess PIP 3 promotes cell …
[HTML][HTML] The excitable signal transduction networks: movers and shapers of eukaryotic cell migration
In response to a variety of external cues, eukaryotic cells display varied migratory modes to
perform their physiological functions during development and in the adult. Aberrations in cell …
perform their physiological functions during development and in the adult. Aberrations in cell …
The PTEN protein: cellular localization and post-translational regulation
NR Leslie, N Kriplani, MA Hermida… - Biochemical Society …, 2016 - portlandpress.com
The phosphatase and tensin homologue deleted on chromosome 10 (PTEN) phosphatase
dephosphorylates PIP3, the lipid product of the class I PI 3-kinases, and suppresses the …
dephosphorylates PIP3, the lipid product of the class I PI 3-kinases, and suppresses the …
Integrating thousands of PTEN variant activity and abundance measurements reveals variant subgroups and new dominant negatives in cancers
KA Matreyek, JJ Stephany, E Ahler, DM Fowler - Genome medicine, 2021 - Springer
Background PTEN is a multi-functional tumor suppressor protein regulating cell growth,
immune signaling, neuronal function, and genome stability. Experimental characterization …
immune signaling, neuronal function, and genome stability. Experimental characterization …