[HTML][HTML] Nanotechnology-based delivery of CRISPR/Cas9 for cancer treatment
Abstract CRISPR/Cas9 (Clustered Regularly Interspaced Short Palindromic Repeats-
associated protein 9) is a potent technology for gene-editing. Owing to its high specificity …
associated protein 9) is a potent technology for gene-editing. Owing to its high specificity …
Fluoropolymers in biomedical applications: state-of-the-art and future perspectives
J Lv, Y Cheng - Chemical Society Reviews, 2021 - pubs.rsc.org
Fluoropolymers have unique physicochemical properties such as hydrophobicity and
lipophobicity, good chemical stability and bio-inertness, low surface energy and phase …
lipophobicity, good chemical stability and bio-inertness, low surface energy and phase …
Blood-brain barrier–penetrating single CRISPR-Cas9 nanocapsules for effective and safe glioblastoma gene therapy
We designed a unique nanocapsule for efficient single CRISPR-Cas9 capsuling,
noninvasive brain delivery and tumor cell targeting, demonstrating an effective and safe …
noninvasive brain delivery and tumor cell targeting, demonstrating an effective and safe …
[HTML][HTML] Stimuli-responsive gene delivery nanocarriers for cancer therapy
Gene therapy provides a promising approach in treating cancers with high efficacy and
selectivity and few adverse effects. Currently, the development of functional vectors with …
selectivity and few adverse effects. Currently, the development of functional vectors with …
[HTML][HTML] In vivo delivery of CRISPR-Cas9 therapeutics: Progress and challenges
Within less than a decade since its inception, CRISPR-Cas9-based genome editing has
been rapidly advanced to human clinical trials in multiple disease areas. Although it is highly …
been rapidly advanced to human clinical trials in multiple disease areas. Although it is highly …
In vivo gene delivery mediated by non-viral vectors for cancer therapy
R Mohammadinejad, A Dehshahri… - Journal of Controlled …, 2020 - Elsevier
Gene therapy by expression constructs or down-regulation of certain genes has shown great
potential for the treatment of various diseases. The wide clinical application of nucleic acid …
potential for the treatment of various diseases. The wide clinical application of nucleic acid …
[HTML][HTML] Inflammatory cytokines in cancer: comprehensive understanding and clinical progress in gene therapy
T Lan, L Chen, X Wei - Cells, 2021 - mdpi.com
The relationship between chronic inflammation and neoplastic diseases is not fully
understood. The inflammatory microenvironment of a tumor is an intricate network that …
understood. The inflammatory microenvironment of a tumor is an intricate network that …
Ligand‐installed nanocarriers toward precision therapy
Abstract Development of drug‐delivery systems that selectively target neoplastic cells has
been a major goal of nanomedicine. One major strategy for achieving this milestone is to …
been a major goal of nanomedicine. One major strategy for achieving this milestone is to …
Fast and efficient CRISPR/Cas9 genome editing in vivo enabled by bioreducible lipid and messenger RNA nanoparticles
J Liu, J Chang, Y Jiang, X Meng, T Sun… - Advanced …, 2019 - Wiley Online Library
A main challenge to broaden the biomedical application of CRISPR/Cas9 (clustered
regularly interspaced short palindromic repeat (CRISPR) associated protein 9) genome …
regularly interspaced short palindromic repeat (CRISPR) associated protein 9) genome …
CRISPR/Cas9-based genome editing for disease modeling and therapy: challenges and opportunities for nonviral delivery
Genome editing offers promising solutions to genetic disorders by editing DNA sequences
or modulating gene expression. The clustered regularly interspaced short palindromic …
or modulating gene expression. The clustered regularly interspaced short palindromic …