Covering: up to 2012 With the recent structural characterization of each of the component
enzymes of type I polyketide synthases, scientists are coming tantalizingly close to …

Natural products from fungi represent an important source of biologically active metabolites
notably for therapeutic agent development. Genome sequencing revealed that the number …

The iterative type I polyketide synthases (IPKSs) are central to the biosynthesis of an
enormously diverse array of natural products in fungi. These natural products, known as …

Fungi are well known for their ability to produce a multitude of natural products. On the one
hand their potential to provide beneficial antibiotics and immunosuppressants has been …

Covering: 1999 to 2014 Type 1, α/β hydrolase-like thioesterase (TE) domains are essential
offloading enzymes, releasing covalently bound products from fatty acid, polyketide, and non …

Covering: 1996–2022 Investigations over the last 2 decades have begun to reveal how
fungal iterative highly-reducing polyketide synthases are programmed. Both in vitro and in …

Time span of literature covered: up to mid-2023 Iterative type I polyketide synthases (iPKSs)
are outstanding natural chemists: megaenzymes that repeatedly utilize their catalytic …

The indolizidine alkaloid swainsonine (SW) is a deadly mycotoxin to livestock that can be
produced by different plant-associated fungi, including the endophytic entomopathogenic …

Dendrodolides A–M (1–13), 13 new 12-membered macrolides, were isolated from
Dendrodochium sp., a fungus associated with the sea cucumber Holothuria nobilis Selenka …

Novel drugs with unique and targeted mode of action are very much need of the hour to treat
and manage severe multidrug infections and other life-threatening complications. Though …