Molecular mechanisms underlying protective role of quercetin in attenuating Alzheimer's disease

E Zaplatic, M Bule, SZA Shah, MS Uddin, K Niaz - Life sciences, 2019 - Elsevier
Quercetin belongs to the flavonoids family, which is present in most of the plants including
fruits, vegetables, green tea and even in red wine having antioxidant activities. It is available …

Alzheimer's disease: a review from the pathophysiology to diagnosis, new perspectives for pharmacological treatment

P dos Santos, C Leide, PF Ozela… - Current medicinal …, 2018 - ingentaconnect.com
Dementia is characterized by the impairment of cognition and behavior of people over 65
years. Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder in the …

EEG signal processing for Alzheimer's disorders using discrete wavelet transform and machine learning approaches

K AlSharabi, YB Salamah, AM Abdurraqeeb… - IEEE …, 2022 - ieeexplore.ieee.org
The most common neurological brain issue is Alzheimer's disease, which can be diagnosed
using a variety of clinical methods. However, the electroencephalogram (EEG) is shown to …

Plants‐derived neuroprotective agents: cutting the cycle of cell death through multiple mechanisms

TO Elufioye, TI Berida… - … and Alternative Medicine, 2017 - Wiley Online Library
Neuroprotection is the preservation of the structure and function of neurons from insults
arising from cellular injuries induced by a variety of agents or neurodegenerative diseases …

Network pharmacology-based and experimental identification of the effects of quercetin on Alzheimer's disease

P Qi, J Li, S Gao, Y Yuan, Y Sun, N Liu, Y Li… - Frontiers in aging …, 2020 - frontiersin.org
Alzheimer's disease (AD) is one of the neurodegenerative brain disorders inducing nearly
half of dementia cases, and the diagnosis and treatment of AD are the primary issues …

EEG-based clinical decision support system for Alzheimer's disorders diagnosis using EMD and deep learning techniques

K AlSharabi, YB Salamah, M Aljalal… - Frontiers in Human …, 2023 - frontiersin.org
Introduction Despite the existence of numerous clinical techniques for identifying
neurological brain disorders in their early stages, Electroencephalogram (EEG) data shows …

Potential therapeutic effects of new ruthenium (III) complex with quercetin: Characterization, structure, gene regulation, and antitumor and anti-inflammatory studies …

MS Refat, RZ Hamza, AMA Adam, HA Saad… - Crystals, 2021 - mdpi.com
The aim of this study was to evaluate the antioxidant and anti-inflammatory effects of the new
[Ru (Q)(Cl) 2 (H2O) 2] complex (RuIII/Q). A new vital complex containing quercetin flavonoid …

De-novo drug design, molecular docking and in-silico molecular prediction of AChEI analogues through CADD approaches as anti-Alzheimer's agents

S Pandey, BK Singh - Current Computer-Aided Drug Design, 2020 - ingentaconnect.com
Background: There are over 44 million persons who suffer with Alzheimer's disease (AD)
worldwide, no existence of cure and only symptomatic treatments are available for it. The …

Elements toward novel therapeutic targeting of the adrenergic system

A Ghanemi, X Hu - Neuropeptides, 2015 - Elsevier
Adrenergic receptors belong to the family of the G protein coupled receptors that represent
important targets in the modern pharmacotherapies. Studies on different physiological and …

Multi-target approach for Alzheimer's disease treatment: computational biomolecular modeling of cholinesterase enzymes with a novel 4-N-phenylaminoquinoline …

FY Adeowo, MA Ejalonibu, AA Elrashedy… - Journal of …, 2021 - Taylor & Francis
The identification of dual inhibitors targeting the active sites of the cholinesterase enzymes,
acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), have lately surfaced as a …