Cardiovascular disease remains the leading cause of death worldwide. A deeper
understanding of the multicellular composition and molecular processes may help to identify …

Allele-specific expression (ASE) is a powerful signal that can be used to investigate multiple
molecular mechanisms, such as cis-regulatory effects and imprinting. Single-cell RNA …

Detecting allelic imbalance at the isoform level requires accounting for inferential
uncertainty, caused by multi-mapping of RNA-seq reads. Our proposed method, SEESAW …

Diploidy has profound implications for population genetics and susceptibility to genetic
diseases. Although two copies are present for most genes in the human genome, they are …

While it is established that the functional impact of genetic variation can vary across cell
types and states, capturing this diversity remains challenging. Current studies using bulk …

Motivation Allelic expression analysis aids in detection of cis-regulatory mechanisms of
genetic variation, which produce allelic imbalance (AI) in heterozygotes. Measuring AI in …

The advent and rapid development of single-cell technologies have made it possible to
study cellular heterogeneity at an unprecedented resolution and scale. Cellular …

Yellowhorn (Xanthoceras sorbifolium), especially its varieties, is the red petal yellowhorn (X.
sorbifolium var. purpurea), an important tree species with great ornamental value, and its …

Abstract Here, we propose DeCAF (DEconvoluted cell type Allele specific Function), a new
method to identify cell-fraction (cf) QTLs in tumors by leveraging both allelic and total …

Behavioural variation is essential for animals to adapt to different social and environmental
conditions. The Kinship Theory of Intragenomic Conflict (KTIC) predicts that parent‐specific …