Structural basis for the inhibition of RecBCD by Gam and its synergistic antibacterial effect with quinolones
M Wilkinson, LA Troman, WAK Wan Nur Ismah… - Elife, 2016 - elifesciences.org
Our previous paper (Wilkinson et al, 2016) used high-resolution cryo-electron microscopy to
solve the structure of the Escherichia coli RecBCD complex, which acts in both the repair of …
solve the structure of the Escherichia coli RecBCD complex, which acts in both the repair of …
[HTML][HTML] Identification of a potent small-molecule inhibitor of bacterial DNA repair that potentiates quinolone antibiotic activity in methicillin-resistant Staphylococcus …
CSQ Lim, KP Ha, RS Clarke, LA Gavin, DT Cook… - Bioorganic & Medicinal …, 2019 - Elsevier
The global emergence of antibiotic resistance is one of the most serious challenges facing
modern medicine. There is an urgent need for validation of new drug targets and the …
modern medicine. There is an urgent need for validation of new drug targets and the …