Up-to-date, accurate information on the disease burden of motor neuron disease (MND) is
the cornerstone for evidence-based resource allocation and healthcare planning. We aimed …

Primary lateral sclerosis (PLS) is a rare neurodegenerative disorder which causes the
selective deterioration of the upper motor neurons (UMNs), sparing the lower motor neuron …

Background In the UK, large-scale electronic primary care datasets can provide up-to-date,
accurate epidemiological information on rarer diseases, where specialist diagnoses from …

Human endogenous retroviruses (HERVs) are DNA transposable elements that have
integrated into the human genome via an ancestral germline infection. The potential …

Neurofilament levels are elevated in many neurodegenerative diseases and have shown
promise as diagnostic and prognostic biomarkers in Amyotrophic Lateral Sclerosis (ALS) …

Electromyograms (EMG) are a recorded galvanic action of nerves and muscles which
assists in diagnosing the disorders associated with muscles and nerves. The efficient …

Background: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease of unknow
etiology. Male sex is a well stablished risk factor, but other factors such as early and adult life …

Background Targeting leptin could represent a rational strategy to treat amyotrophic lateral
sclerosis (ALS), as previously clinical studies have shown its levels to be associated with a …

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that affects
both the upper and lower motor neurons in the nervous system, causing muscle weakness …

Introduction Advances in machine learning (ML) methodologies, combined with
multidisciplinary collaborations across biological and physical sciences, has the potential to …