Age is the key risk factor for diseases and disabilities of the elderly. Efforts to tackle age-
related diseases and increase healthspan have suggested targeting the ageing process …

Immortal time is a span of cohort follow-up during which, because of exposure definition, the
outcome under study could not occur. Bias from immortal time was first identified in the …

Background: Lung cancer is the leading cause of cancer death worldwide, and about one
half of patients with lung cancer are active smokers at diagnosis. Objective: To determine …

Objective To assess whether statin treatment is associated with a reduction in
atherosclerotic cardiovascular disease (CVD) and mortality in old and very old adults with …

Problem of immortal time bias in cohort studies: example using statins for preventing
progression of diabetes | The BMJ Skip to main content Intended for healthcare …

Background—Current observational studies on warfarin use and the risk for stroke and
bleeding in patients with atrial fibrillation (AF) undergoing dialysis found conflicting results …

Background: Millions of women worldwide use exogenous hormones as oral contraceptives
or hormone replacement therapy. Still, time-dependent and long-term consequences of …

Context Prior mechanistic studies reported that omeprazole decreases the platelet inhibitory
effects of clopidogrel, yet the clinical significance of these findings is not clear. Objective To …

Vitamin E improves liver histology in adults with nonalcoholic steatohepatitis (NASH) but not
diabetes, but its impact on long‐term patient outcomes is unknown. We evaluated whether …

Background Revision for prosthetic joint infection (PJI) has a major effect on patients' health
but it remains unclear if early PJI after primary THA is associated with a high mortality …