Droplet microfluidics has revolutionized the study of single cells. The ability to
compartmentalize cells within picoliter droplets in microfluidic devices has opened up a wide …

Over 17 and 160 types of chemical modifications have been identified in DNA and RNA,
respectively. The interest in understanding the various biological functions of DNA and RNA …

Abstract N 6-methyladenosine (m6A) is the most abundant RNA modification in mammalian
cells and the best-studied epitranscriptomic mark. Despite the development of various tools …

Bisulfite sequencing has been the gold standard for mapping DNA modifications including 5-
methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) for decades,,–. However, this …

A DNA sequence is the hard copy of the human genome and it is a driving force in
determining the physiological processes in an organism. Concurrently, the chemical …

DNA methylation plays a fundamental role in the control of gene expression and genome
integrity. Although there are multiple tools that enable its detection from Nanopore …

DNA and RNA modifications have important functions, including the regulation of gene
expression. Existing methods based on short-read sequencing for the detection of …

In the biogeochemical cycle, sulfur oxidation plays a vital role and is typically referred to as
the elemental sulfur or reductive sulfide oxidation process. This study aimed to characterize …

Although various methods have been developed for sequencing cytosine modifications, it is
still challenging for specific and quantitative sequencing of individual modification at base …

Conspectus Protein–DNA interactions are important in replication, transcription, repair, as
well as epigenetic modifications of DNA, which involve methylation and demethylation of …