Piperazine is one of the most sought heterocyclics for the development of new drug
candidates. This ring can be traced in a number of well established, commercially available …

Bacterial topoisomerase inhibitors continue to be actively developed as clinical antibacterial
agents, largely owing to the success of the currently marketed inhibitors, the quinolones, and …

The quinolone-3-carboxylic acid scaffold is essential structure for antibacterial activity of
fluoroquinolones such as ciprofloxacin. Modification of 3-carboxylic functionality in this …

Ciprofloxacin is a broad-spectrum antibiotic that plays an important role in inhibiting the
growth of both Gram-positive and Gram-negative bacteria. Medicinal chemists are …

Antimicrobial resistance poses a global health concern and develops a need to discover
novel antimicrobial agents or targets to tackle this problem. Fluoroquinolone (FN), a DNA …

A number of gatifloxacin analogues containing a nitroaryl-1, 3, 4-thiadiazole moiety attached
to the piperazine ring at C-7 position were prepared and evaluated as antibacterial agents …

Enoxacin, levofloxacin, and gatifloxacin represent one of the most important prerogative
scaffolds in drug development. They possess broad spectrum antimicrobial and anti …

Diabetes mellitus is a multifactorial global health disorder that is rising at an alarming rate.
One effective therapeutic approach for controlling hyperglycemia associated with type-2 …

Metal complexes with the third-generation quinolone antibacterial agent sparfloxacin (SPFX)
or 5-amino-1-cyclopropyl-7-(cis-3, 5-dimethyl-1-piperazinyl)-6, 8, di-fluoro-1-4-dihydro-4-oxo …

A comprehensive review of advances in the synthesis and biological applications of
enoxacin (1, referred to as ENX)-based compounds is presented. ENX, a second-generation …