Cellular homeostasis and adaptation to various environmental conditions are importantly
regulated by the sophisticated mechanism of autophagy and its crosstalk with Wnt signaling …

Aging accompanied by several age-related complications, is a multifaceted inevitable
biological progression involving various genetic, environmental, and lifestyle factors. The …

Lung cancer is a main cause of death all over the world with a high incidence rate.
Metastasis into neighboring and distant tissues as well as resistance of cancer cells to …

Oxidative stress and AKT serine-threonine kinase (AKT) are responsible for regulating
several cell functions of cancer cells. Several natural products modulate both oxidative …

Emerging scientific evidence indicates that inflammation is a critical component of tumor
promotion and progression. Most cancers originate from sites of chronic irritation, infections …

Abstract Cyclin-dependent kinase 12 (CDK12) is a member of the CDK family of proteins
(CDK) and is critical for cancer development. Years of study into CDK12 have generated …

Surgery is the common treatment for early lung cancer with multiple pulmonary nodules, but
it is often accompanied by the problem of significant malignancy of other nodules in non …

Cardiac glycosides (CGs) have a long history of treating cardiac diseases. However, recent
reports have suggested that CGs also possess anticancer and antiviral activities. The …

Cardiac glycosides are natural sterols and constitute a group of secondary metabolites
isolated from plants and animals. These cardiotonic agents are well recognized and …

Autophagy is a self-digestion process in cells that can maintain energy homeostasis under
normal circumstances. However, misfolded proteins, damaged mitochondria and other …