Na+, K+-ATPase is the only known receptor of cardiotonic steroids (CTS) whose interaction
with catalytic α-subunits leads to inhibition of this enzyme. As predicted, CTS affect …

Cardiovascular disease, predominantly ischemic heart disease (IHD), is the leading cause
of death in diabetes mellitus (DM). In addition to eliciting cardiomyopathy, DM induces a …

Bufalin is the primary component of the traditional Chinese medicine “Chan Su,” which has
been widely used for cancer treatment at oncology clinics in certain countries. Evidence …

It is widely anticipated that a reduction of brain levels of the cellular prion protein (PrPC) can
prolong survival in a group of neurodegenerative diseases known as prion diseases. To …

Mutations in the RS1 gene cause X-linked juvenile retinoschisis (XLRS), a hereditary retinal
dystrophy. We recently showed that retinoschisin, the protein encoded by RS1, regulates …

Transforming growth factor-beta (TGF-β) is a multi-functional cytokine implicated in the
control of cell growth and differentiation. TGF-β signals through a complex of TGF-β …

In recent years, Na/K-ATPase signaling has been implicated in different physiological and
pathophysiological conditions, including cardiac hypertrophy and uremic cardiomyopathy …

Bufadienolides are cardiotonic steroids (CTS) identified in mammals. Besides Na+/K+-
ATPase inhibition, they activate signal transduction via protein–protein interactions. Diversity …

The prion protein (PrP) is best known for its ability to cause fatal neurodegenerative
diseases in humans and animals. Here, we revisited its molecular environment in the brain …

Both a diet rich in fructose and chronic stress exposure induce metabolic and cardiovascular
disturbances. The aim of this study was to examine the effects of the fructose-rich diet and …