Inhibitory potential of nitrogen, oxygen and sulfur containing heterocyclic scaffolds against acetylcholinesterase and butyrylcholinesterase
Heterocycles are the key structures in organic chemistry owing to their immense applications
in the biological, chemical, and pharmaceutical fields. Heterocyclic compounds perform …
in the biological, chemical, and pharmaceutical fields. Heterocyclic compounds perform …
A comprehensive review on triazole based conjugates as acetylcholinesterase inhibitors: Design strategies, synthesis, biological activity, structure activity …
Significant advancements have been made in development of Acetylcholinesterase
inhibitors as Anti-Alzheimer drugs. Triazoles, a 5-membered heterocyclic nucleus containing …
inhibitors as Anti-Alzheimer drugs. Triazoles, a 5-membered heterocyclic nucleus containing …
Synthesis, in-vitro, in-vivo anti-inflammatory activities and molecular docking studies of acyl and salicylic acid hydrazide derivatives
A Munir, A Khushal, K Saeed, A Sadiq, R Ullah, G Ali… - Bioorganic …, 2020 - Elsevier
Over the course of time several drugs have been synthesized and are available in market for
the treatment of inflammation. However, they were unable to cure effectively and associated …
the treatment of inflammation. However, they were unable to cure effectively and associated …
[HTML][HTML] 2-methylindole analogs as cholinesterases and glutathione S-transferase inhibitors: Synthesis, biological evaluation, molecular docking, and pharmacokinetic …
In this study, we aimed to (i) synthesize new 2-methylindole analogs containing various
amino structures, pyrrolidine, piperidine, morpholine, and substituted phenyl groups through …
amino structures, pyrrolidine, piperidine, morpholine, and substituted phenyl groups through …
Novel pyrazoline linked acyl thiourea pharmacophores as antimicrobial, urease, amylase and α-glucosidase inhibitors: design, synthesis, SAR and molecular docking …
In the present work, a small library of novel pyrazolinyl-acyl thiourea (5a–j) was designed
and synthesized through a multistep sequence and the synthesized compounds were …
and synthesized through a multistep sequence and the synthesized compounds were …
Design, synthesis and biological evaluation of some new 2-Pyrazoline derivatives as potential anticancer agents
A new series of N-(4-(1-Phenyl-5-aryl-4, 5-dihydro-1H-pyrazol-3-yl) phenyl)-4-
substitutedbenzamide derivatives were designed and synthesized from new chalcone …
substitutedbenzamide derivatives were designed and synthesized from new chalcone …
A series of 1, 2, 3-triazole compounds: Synthesis, characterization, and investigation of the cholinesterase inhibitory properties via in vitro and in silico studies
Abstract A series of 1, 2, 3-triazole compounds derived from a salicylaldehyde moiety were
synthesized in high yields using copper (I)-catalyzed azide-alkyne cycloaddition (CuAAC) …
synthesized in high yields using copper (I)-catalyzed azide-alkyne cycloaddition (CuAAC) …
Design, Synthesis and Biological Activities of (Thio) Urea Benzothiazole Derivatives
JE Mendieta-Wejebe, MC Rosales-Hernández… - International Journal of …, 2023 - mdpi.com
(Thio) ureas ((T) Us) and benzothiazoles (BTs) each have demonstrated to have a great
variety of biological activities. When these groups come together, the 2-(thio) …
variety of biological activities. When these groups come together, the 2-(thio) …
[HTML][HTML] Exploring the multi-target enzyme inhibition potential of new sulfonamido-thiazoline derivatives; synthesis and computational studies
A small library of ten new Nimesulide-iminothiazolines conjugates was synthesized by the
reduction of nitro group of Nimesulide followed by conversion into variously substituted acyl …
reduction of nitro group of Nimesulide followed by conversion into variously substituted acyl …
Synthesis, structure elucidation, SC-XRD/DFT, molecular modelling simulations and DNA binding studies of 3,5-diphenyl-4,5-dihydro-1H-pyrazole chalcones
Deoxyribonucleic acid (DNA) acts as the most important intracellular target for various drugs.
Exploring the DNA binding interactions of small bioactive molecules offers a structural …
Exploring the DNA binding interactions of small bioactive molecules offers a structural …