Disorders of central nervous system (CNS) disorders are considered serious health issues.
The most common CNS diseases include neurodegenerative diseases, mental disorders …

Neurological and neurodegenerative diseases, particularly those related to aging, are on
the rise, but drug therapies are rarely curative. Functional disorders and the organic …

Numerous animal and human studies have assessed the relationship between polyphenols
and outcomes related to depression. However, no comprehensive synthesis of the main …

Significant levels of flavonoids with antioxidant properties can be found in citrus species.
Flavonoids are a class of plant chemical known for a wide range of pharmacological …

After the development of “classical” tricyclic antidepressants and monoamine oxidase
inhibitors, numerous other classes of antidepressant drugs have been introduced onto the …

Rationale Depression is a psychiatric disorder that constitutes one of the leading causes of
disability worldwide. 2-Phenyl-3-(phenylselanyl) benzofuran (SeBZF 1) has been studied as …

Methylglyoxal (MGO) is an endogenous toxin, mainly produced as a by-product of glycolysis
that has been associated to aging, Alzheimer's disease, and inflammation. Cell culture …

Depressive disorders are among the most disabling diseases experienced around the
world, and their incidence has significantly increased over the last few decades due to …

Rationale and objective Estradiol decline has been associated with depression and anxiety
in post-menopausal women. Agomelatine (Ago) is an agonist of the melatonergic MT1/MT2 …

Previous studies have shown that hesperidin may have beneficial effects on depression;
however, to the best of our knowledge, no clinical trial has yet been conducted in this area …