Targeted therapy has been a very promising strategy of drug development research. Many
molecular mechanims of diseases have been known to be regulated by abundance of …

Chemoprevention, a relatively new and promising strategy to prevent cancer, is defined as
the use of natural dietary compounds and/or synthetic substances to block, inhibit, reverse …

Dietary flavonoids and other polyphenols show great potential as cancer chemopreventive
agents in cell culture studies. This does not translate well into in vivo activity, because of …

Citrus fruit and in particular flavonoid compounds from citrus peel have been identified as
agents with utility in the treatment of cancer. This review provides a background and …

Polymethoxyflavones (PMFs) and hydroxylated polymethoxyflavones exist exclusively in
citrus genus, especially in the citrus peels which have been used as herbal medicine for …

Tangeretin and nobiletin are citrus flavonoids that are among the most effective at inhibiting
cancer cell growth in vitro and in vivo. The antiproliferative activity of tangeretin and nobiletin …

Tangeretin (5, 6, 7, 8, 4′-pentamethoxyflavone) is a polymethoxylated flavonoid
concentrated in the peel of citrus fruits. Recent studies have shown that tangeretin exhibits …

Fruits and vegetables have long been recognized as potentially important in the prevention
of cancer risk. Thus, scientific interest in nutrition and cancer has grown over time, as shown …

To date, cancer is the second leading cause of death worldwide after cardiac arrest. A large
number of synthetic drugs are available for the treatment of different types of cancer; …

Objective NLRP3 inflammasome-mediated pyroptosis of macrophage acts essential roles in
the progression of sepsis-induced acute lung injury (ALI). Tangeretin (TAN), enriched in …