[HTML][HTML] Clinical relevance of blood-based ctDNA analysis: mutation detection and beyond

L Keller, Y Belloum, H Wikman, K Pantel - British journal of cancer, 2021 - nature.com
Cell-free DNA (cfDNA) derived from tumours is present in the plasma of cancer patients. The
majority of currently available studies on the use of this circulating tumour DNA (ctDNA) deal …

Circulating tumor DNA and liquid biopsy in oncology

DW Cescon, SV Bratman, SM Chan, LL Siu - Nature cancer, 2020 - nature.com
Techniques for analyzing circulating tumor DNA (ctDNA) to detect, characterize and monitor
cancer have matured rapidly. An increasing body of clinical evidence is demonstrating the …

ctDNA guiding adjuvant immunotherapy in urothelial carcinoma

T Powles, ZJ Assaf, N Davarpanah, R Banchereau… - Nature, 2021 - nature.com
Minimally invasive approaches to detect residual disease after surgery are needed to
identify patients with cancer who are at risk for metastatic relapse. Circulating tumour DNA …

Perioperative ctDNA-based molecular residual disease detection for non–small cell lung cancer: a prospective multicenter cohort study (LUNGCA-1)

L Xia, J Mei, R Kang, S Deng, Y Chen, Y Yang… - Clinical Cancer …, 2022 - AACR
Purpose: We assessed whether perioperative circulating tumor DNA (ctDNA) could be a
biomarker for early detection of molecular residual disease (MRD) and prediction of …

Monitoring and adapting cancer treatment using circulating tumor DNA kinetics: Current research, opportunities, and challenges

E Sanz-Garcia, E Zhao, SV Bratman, LL Siu - Science Advances, 2022 - science.org
Circulating tumor DNA (ctDNA) has emerged as a biomarker with wide-ranging applications
in cancer management. While its role in guiding precision medicine in certain tumors via …

Circulating tumor DNA analyses as markers of recurrence risk and benefit of adjuvant therapy for stage III colon cancer

J Tie, JD Cohen, Y Wang, M Christie, K Simons… - JAMA …, 2019 - jamanetwork.com
Importance Adjuvant chemotherapy in patients with stage III colon cancer prevents
recurrence by eradicating minimal residual disease. However, which patients remain at high …

Current and future clinical applications of ctDNA in immuno-oncology

JC Stadler, Y Belloum, B Deitert, M Sementsov… - Cancer Research, 2022 - AACR
Testing peripheral blood for circulating tumor DNA (ctDNA) offers a minimally invasive
opportunity to diagnose, characterize, and monitor the disease in individual cancer patients …

Impact of circulating tumor DNA–based detection of molecular residual disease on the conduct and design of clinical trials for solid tumors

PM Kasi, G Fehringer, H Taniguchi, N Starling… - JCO Precision …, 2022 - ascopubs.org
PURPOSE Earlier detection of cancer recurrence using circulating tumor DNA (ctDNA) to
detect molecular residual disease (MRD) has the potential to dramatically affect cancer …

[HTML][HTML] The molecular profiling of solid tumors by liquid biopsy: A position paper of the AIOM–SIAPEC-IAP–SIBioC–SIC–SIF Italian Scientific Societies

A Russo, L Incorvaia, M Del Re, U Malapelle… - ESMO open, 2021 - Elsevier
The term liquid biopsy (LB) refers to the use of various biological fluids as a surrogate for
neoplastic tissue to achieve information for diagnostic, prognostic and predictive purposes …

Current and emerging applications of droplet digital PCR in oncology: an updated review

S Olmedillas-López, R Olivera-Salazar… - Molecular Diagnosis & …, 2022 - Springer
In the era of personalized medicine and targeted therapies for the management of patients
with cancer, ultrasensitive detection methods for tumor genotyping, such as next-generation …