Protein lysine acetylation is an important posttranslational modification that regulates
numerous biological processes. Targeting lysine acetylation regulatory factors, such as …

In mammals, seven members of the sirtuin protein family known as class III histone
deacetylase have been identified for their characteristic features. These distinguished …

Background: High salt intake is the leading dietary risk factor for cardiovascular diseases.
Although clinical evidence suggests that high salt intake is associated with nonalcoholic fatty …

While loss of antioxidant expression and the resultant oxidant-dependent damage to cellular
macromolecules is key to tumorigenesis, it has become evident that effective oxidant …

Cigarette smoke (CS)-induced oxidative stress drives the pathogenesis of respiratory
diseases, in which the activation and accumulation of reactive oxygen species (ROS) play …

Highlights•SIRT3, a major deacetylase in mitochondria, regulates almost every aspect of
mitochondrial health and functionality.•SIRT3 controls vital functions like energy balance …

Osteoarthritis (OA) is a multifactorial arthritic disease of weight-bearing joints concomitant
with chronic and intolerable pain, loss of locomotion and impaired quality of life in the elderly …

Mitochondrial dysregulation has been implicated in oxidative stress-induced melanocyte
destruction in vitiligo. However, the molecular mechanism underlying this process is merely …

In addition to the lung, the liver is considered another major target for paraquat (PQ)
poisoning. Hydrogen sulfide (H2S) has been demonstrated to be effective in the inhibition of …

Osteoarthritis is the most common degenerative joint disease and causes major pain and
disability in adults. It has been reported that mitochondrial dysfunction in chondrocytes is …