Ovarian cancer (OC) is a heterogeneous disease with the highest mortality rate and the
poorest prognosis among gynecological malignancies. Because of the absence of specific …

Alternative splicing is a widespread process contributing to structural transcript variation and
proteome diversity. In cancer, the splicing process is commonly disrupted, resulting in both …

We present primary results from the Sequencing Quality Control (SEQC) project,
coordinated by the US Food and Drug Administration. Examining Illumina HiSeq, Life …

Atherosclerosis underlies the predominant number of cardiovascular diseases and remains
a leading cause of morbidity and mortality worldwide. The development, progression and …

The concordance of RNA-sequencing (RNA-seq) with microarrays for genome-wide
analysis of differential gene expression has not been rigorously assessed using a range of …

Despite growing appreciation of the importance of long noncoding RNAs (lncRNAs) in
normal physiology and disease, our knowledge of cancer-related lncRNAs remains limited …

Although several dozen studies of gene expression in sepsis have been published,
distinguishing sepsis from a sterile systemic inflammatory response syndrome (SIRS) is still …

The advent of next generation sequencing (NGS) technologies has revolutionized the field
of genomics, enabling fast and cost-effective generation of genome-scale sequence data …

The mutagenic effect of hepatitis B (HBV) integration in predisposing risk to hepatocellular
carcinoma (HCC) remains elusive. In this study, we performed transcriptome sequencing of …

Inherited retinal diseases (IRDs) cause progressive loss of light-sensitive photoreceptors in
the eye and can lead to blindness. Gene-based therapies for IRDs have shown remarkable …