Functional relationship between osteogenesis and angiogenesis in tissue regeneration

F Diomede, GD Marconi, L Fonticoli… - International Journal of …, 2020 - mdpi.com
Bone tissue renewal can be outlined as a complicated mechanism centered on the
interaction between osteogenic and angiogenic events capable of leading to bone formation …

A road map for understanding molecular and genetic determinants of osteoporosis

TL Yang, H Shen, A Liu, SS Dong, L Zhang… - Nature Reviews …, 2020 - nature.com
Osteoporosis is a highly prevalent disorder characterized by low bone mineral density and
an increased risk of fracture, termed osteoporotic fracture. Notably, bone mineral density …

Fate decision of mesenchymal stem cells: adipocytes or osteoblasts?

Q Chen, P Shou, C Zheng, M Jiang, G Cao… - Cell Death & …, 2016 - nature.com
Mesenchymal stem cells (MSCs), a non-hematopoietic stem cell population first discovered
in bone marrow, are multipotent cells capable of differentiating into mature cells of several …

Mesenchymal stem cells: cell fate decision to osteoblast or adipocyte and application in osteoporosis treatment

L Hu, C Yin, F Zhao, A Ali, J Ma, A Qian - International Journal of …, 2018 - mdpi.com
Osteoporosis is a progressive skeletal disease characterized by decreased bone mass and
degraded bone microstructure, which leads to increased bone fragility and risks of bone …

Osteoblast differentiation and signaling: established concepts and emerging topics

M Ponzetti, N Rucci - International Journal of Molecular Sciences, 2021 - mdpi.com
Osteoblasts, the cells that build up our skeleton, are remarkably versatile and important cells
that need tight regulation in all the phases of their differentiation to guarantee proper skeletal …

TGF-β/BMP signaling and other molecular events: regulation of osteoblastogenesis and bone formation

MS Rahman, N Akhtar, HM Jamil, RS Banik… - Bone research, 2015 - nature.com
Transforming growth factor-beta (TGF-β)/bone morphogenetic protein (BMP) plays a
fundamental role in the regulation of bone organogenesis through the activation of receptor …

Senile osteoporosis: the involvement of differentiation and senescence of bone marrow stromal cells

A Qadir, S Liang, Z Wu, Z Chen, L Hu… - International journal of …, 2020 - mdpi.com
Senile osteoporosis has become a worldwide bone disease with the aging of the world
population. It increases the risk of bone fracture and seriously affects human health. Unlike …

Adipose‐derived stem cells for tissue engineering and regenerative medicine applications

R Dai, Z Wang, R Samanipour, K Koo… - Stem cells …, 2016 - Wiley Online Library
Adipose‐derived stem cells (ASCs) are a mesenchymal stem cell source with properties of
self‐renewal and multipotential differentiation. Compared to bone marrow‐derived stem …

Development of micro RNA therapeutics is coming of age

E Van Rooij, S Kauppinen - EMBO molecular medicine, 2014 - embopress.org
Micro RNA s (mi RNA s) play key regulatory roles in diverse biological processes and are
frequently dysregulated in human diseases. Thus, mi RNA s have emerged as a class of …

miR-214 targets ATF4 to inhibit bone formation

X Wang, B Guo, Q Li, J Peng, Z Yang, A Wang, D Li… - Nature medicine, 2013 - nature.com
Emerging evidence indicates that microRNAs (miRNAs) have important roles in regulating
osteogenic differentiation and bone formation. Thus far, no study has established the …