COVID‐19 and toll‐like receptor 4 (TLR4): SARS‐CoV‐2 may bind and activate TLR4 to increase ACE2 expression, facilitating entry and causing hyperinflammation
MM Aboudounya, RJ Heads - Mediators of inflammation, 2021 - Wiley Online Library
Causes of mortality from COVID‐19 include respiratory failure, heart failure, and
sepsis/multiorgan failure. TLR4 is an innate immune receptor on the cell surface that …
sepsis/multiorgan failure. TLR4 is an innate immune receptor on the cell surface that …
[HTML][HTML] A review of SARS-CoV-2 disease (COVID-19): pandemic in our time
N Al-Awwal, F Dweik, S Mahdi, M El-Dweik… - Pathogens, 2022 - mdpi.com
Development and deployment of biosensors for the rapid detection of the 2019 novel severe
acute respiratory syndrome—coronavirus 2 (SARS-CoV-2) are of utmost importance and …
acute respiratory syndrome—coronavirus 2 (SARS-CoV-2) are of utmost importance and …
[HTML][HTML] Structure based pharmacophore modeling, virtual screening, molecular docking and ADMET approaches for identification of natural anti-cancer agents …
X-linked inhibitor of apoptosis protein (XIAP) is a member of inhibitor of apoptosis protein
(IAP) family responsible for neutralizing the caspases-3, caspases-7, and caspases-9 …
(IAP) family responsible for neutralizing the caspases-3, caspases-7, and caspases-9 …
[HTML][HTML] An in silico deep learning approach to multi-epitope vaccine design: a SARS-CoV-2 case study
The rampant spread of COVID-19, an infectious disease caused by SARS-CoV-2, all over
the world has led to over millions of deaths, and devastated the social, financial and political …
the world has led to over millions of deaths, and devastated the social, financial and political …
[HTML][HTML] Amentoflavone derivatives significantly act towards the main protease (3CLPRO/MPRO) of SARS-CoV-2: in silico admet profiling, molecular docking …
SARS-CoV-2 is the foremost culprit of the novel coronavirus disease 2019 (nCoV-19 and/or
simply COVID-19) and poses a threat to the continued life of humans on the planet and …
simply COVID-19) and poses a threat to the continued life of humans on the planet and …
[HTML][HTML] Designing of a next generation multiepitope based vaccine (MEV) against SARS-COV-2: Immunoinformatics and in silico approaches
Coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory
coronavirus 2 (SARS-COV-2) is a significant threat to global health security. Till date, no …
coronavirus 2 (SARS-COV-2) is a significant threat to global health security. Till date, no …
Pharmacoinformatics and molecular dynamics simulation-based phytochemical screening of neem plant (Azadiractha indica) against human cancer by targeting …
Minichromosome maintenance complex component 7 (MCM7) belongs to the
minichromosome maintenance family that is important for the initiation of eukaryotic DNA …
minichromosome maintenance family that is important for the initiation of eukaryotic DNA …
GESS: a database of global evaluation of SARS-CoV-2/hCoV-19 sequences
The COVID-19 outbreak has become a global emergency since December 2019. Analysis of
SARS-CoV-2 sequences can uncover single nucleotide variants (SNVs) and corresponding …
SARS-CoV-2 sequences can uncover single nucleotide variants (SNVs) and corresponding …
Design of a multi-epitope-based vaccine targeting M-protein of SARS-CoV2: an immunoinformatics approach
VS Ayyagari, V TC, AP K, K Srirama - Journal of biomolecular …, 2022 - Taylor & Francis
In the present study, one of the targets present on the envelopes of coronaviruses,
membrane glycoprotein (M) was chosen for the design of a multi-epitope vaccine by …
membrane glycoprotein (M) was chosen for the design of a multi-epitope vaccine by …
Peptides for vaccine development
IW Hamley - ACS Applied Bio Materials, 2022 - ACS Publications
This review discusses peptide epitopes used as antigens in the development of vaccines in
clinical trials as well as future vaccine candidates. It covers peptides used in potential …
clinical trials as well as future vaccine candidates. It covers peptides used in potential …