Antibiotic perturbations to the gut microbiome
Antibiotic-mediated perturbation of the gut microbiome is associated with numerous
infectious and autoimmune diseases of the gastrointestinal tract. Yet, as the gut microbiome …
infectious and autoimmune diseases of the gastrointestinal tract. Yet, as the gut microbiome …
Antibiotic-induced collateral damage to the microbiota and associated infections
Antibiotics have transformed medicine, saving millions of lives since they were first used to
treat a bacterial infection. However, antibiotics administered to target a specific pathogen …
treat a bacterial infection. However, antibiotics administered to target a specific pathogen …
[HTML][HTML] Klebsiella pneumoniae induces inflammatory bowel disease through caspase-11–mediated IL18 in the gut epithelial cells
Q Zhang, X Su, C Zhang, W Chen, Y Wang… - Cellular and Molecular …, 2023 - Elsevier
Background & Aims Klebsiella pneumoniae (KLP), a Gram-negative bacterium belonging to
the family of Enterobacteriaceae, is a common cause of antimicrobial-resistant opportunistic …
the family of Enterobacteriaceae, is a common cause of antimicrobial-resistant opportunistic …
In situ, in vivo, and in vitro approaches for studying AMR plasmid conjugation in the gut microbiome
C Kessler, J Hou, O Neo… - FEMS Microbiology …, 2023 - academic.oup.com
Antimicrobial resistance (AMR) is a global threat, with evolution and spread of resistance to
frontline antibiotics outpacing the development of novel treatments. The spread of AMR is …
frontline antibiotics outpacing the development of novel treatments. The spread of AMR is …
[HTML][HTML] Differential mucosal tropism and dissemination of classical and hypervirulent Klebsiella pneumoniae infection
Klebsiella pneumoniae (Kp) infection is an important healthcare concern. The ST258
classical (c) Kp strain is dominant in hospital-acquired infections in North America and …
classical (c) Kp strain is dominant in hospital-acquired infections in North America and …
[HTML][HTML] Spatial analysis of murine microbiota and bile acid metabolism during amoxicillin treatment
CN Beekman, S Penumutchu, R Peterson, G Han… - Cell Reports, 2024 - cell.com
Antibiotics cause collateral damage to resident microbes that is associated with various
health risks. To date, studies have largely focused on the impacts of antibiotics on large …
health risks. To date, studies have largely focused on the impacts of antibiotics on large …
Raising the alarm: fosfomycin resistance associated with non-susceptible inner colonies imparts no fitness cost to the primary bacterial uropathogen
TA Bermudez, JR Brannon, N Dudipala… - Antimicrobial Agents …, 2024 - Am Soc Microbiol
Fosfomycin kills bacteria by blocking the binding of phosphoenolpyruvate (PEP) to the
bacterial enzyme MurA and halting peptidoglycan synthesis. While fosfomycin use has …
bacterial enzyme MurA and halting peptidoglycan synthesis. While fosfomycin use has …
Intestinal dominance by multidrug-resistant bacteria in pediatric liver transplant patients
E Dahdouh, L Fernández-Tomé… - Microbiology …, 2022 - Am Soc Microbiol
Pediatric liver transplantation (PLTx) is commonly associated with extensive antibiotic
treatments that can produce gut microbiome alterations and open the way to dominance by …
treatments that can produce gut microbiome alterations and open the way to dominance by …
[HTML][HTML] Intestinal loads of extended-spectrum beta-lactamase and Carbapenemase genes in critically ill pediatric patients
E Dahdouh, E Cendejas-Bueno… - Frontiers in Cellular …, 2023 - frontiersin.org
Introduction Intestinal colonization by Multi-Drug Resistant Organisms (MDROs) can pose a
threat on the health of critically ill patients. The extent of colonization by these organisms is …
threat on the health of critically ill patients. The extent of colonization by these organisms is …
Extensively acquired antimicrobial resistant bacteria restructure the individual microbial community in post-antibiotic conditions
JW Baek, S Lim, N Park, B Song, N Kirtipal, J Nielsen… - bioRxiv, 2024 - biorxiv.org
In recent years, the overuse of antibiotics has led to the emergence of antimicrobial resistant
(AMR) bacteria. To evaluate the spread of AMR bacteria, the reservoir of AMR genes …
(AMR) bacteria. To evaluate the spread of AMR bacteria, the reservoir of AMR genes …