Antibiotic-mediated perturbation of the gut microbiome is associated with numerous
infectious and autoimmune diseases of the gastrointestinal tract. Yet, as the gut microbiome …

Antibiotics have transformed medicine, saving millions of lives since they were first used to
treat a bacterial infection. However, antibiotics administered to target a specific pathogen …

Background & Aims Klebsiella pneumoniae (KLP), a Gram-negative bacterium belonging to
the family of Enterobacteriaceae, is a common cause of antimicrobial-resistant opportunistic …

Antimicrobial resistance (AMR) is a global threat, with evolution and spread of resistance to
frontline antibiotics outpacing the development of novel treatments. The spread of AMR is …

Klebsiella pneumoniae (Kp) infection is an important healthcare concern. The ST258
classical (c) Kp strain is dominant in hospital-acquired infections in North America and …

Antibiotics cause collateral damage to resident microbes that is associated with various
health risks. To date, studies have largely focused on the impacts of antibiotics on large …

Fosfomycin kills bacteria by blocking the binding of phosphoenolpyruvate (PEP) to the
bacterial enzyme MurA and halting peptidoglycan synthesis. While fosfomycin use has …

Pediatric liver transplantation (PLTx) is commonly associated with extensive antibiotic
treatments that can produce gut microbiome alterations and open the way to dominance by …

Introduction Intestinal colonization by Multi-Drug Resistant Organisms (MDROs) can pose a
threat on the health of critically ill patients. The extent of colonization by these organisms is …

In recent years, the overuse of antibiotics has led to the emergence of antimicrobial resistant
(AMR) bacteria. To evaluate the spread of AMR bacteria, the reservoir of AMR genes …