Matrix metalloproteinases (MMPs) and a disintegrin and metalloproteinases (ADAMs)
belong to the metzincin family of zinc-containing multidomain molecules, and can act as …

Cystic fibrosis (CF) is caused by defects in an anion channel, the cystic fibrosis
transmembrane conductance regulator (CFTR). Recently, a new airway epithelial cell type …

Current kidney organoids model development and diseases of the nephron but not the
contiguous epithelial network of the kidney's collecting duct (CD) system. Here, we report the …

The assignment of cell type names to individual cell clusters in single-cell RNA-sequencing
(RNA-seq; including single-nucleus RNA-seq) studies is a critical bioinformatic step …

Intercalated cells (ICs) are found in the connecting tubule and the collecting duct. Of the
three IC subtypes identified, type B intercalated cells are one of the best characterized and …

Organoid technology is rapidly gaining ground for studies on organ (patho) physiology.
Tubuloids are long-term expanding organoids grown from adult kidney tissue or urine. The …

Summary Fibroblast growth factor 10 (FGF10) is well established as a mesenchyme-derived
growth factor and a critical regulator of fetal organ development in mice and humans. Using …

Epidemiological studies document strong associations between acute or chronic kidney
injury and kidney tumors. However, whether these associations are linked by causation, and …

A revolution in cellular measurement technology is underway. Whereas prior studies have
been able to analyze only the averaged outputs from renal tissue, we now can accurately …

Kidney development involves formation of nephrons intricately aligned with the vasculature
and connected to a branched network of collecting ducts. Notch signaling plays multiple …