Prebiotic peptides: Molecular hubs in the origin of life

M Frenkel-Pinter, M Samanta, G Ashkenasy… - Chemical …, 2020 - ACS Publications
The fundamental roles that peptides and proteins play in today's biology makes it almost
indisputable that peptides were key players in the origin of life. Insofar as it is appropriate to …

Polyelectrolyte complex coacervates: Recent developments and new frontiers

AM Rumyantsev, NE Jackson… - Annual Review of …, 2021 - annualreviews.org
Polyelectrolyte complex coacervates represent a wide class of materials with applications
ranging from coatings and adhesives to pharmaceutical technologies. They also underpin …

Living material assembly of bacteriogenic protocells

C Xu, N Martin, M Li, S Mann - Nature, 2022 - nature.com
Advancing the spontaneous bottom-up construction of artificial cells with high organizational
complexity and diverse functionality remains an unresolved issue at the interface between …

Nanoparticle-assembled bioadhesive coacervate coating with prolonged gastrointestinal retention for inflammatory bowel disease therapy

P Zhao, X Xia, X Xu, KKC Leung, A Rai, Y Deng… - Nature …, 2021 - nature.com
A key challenge for the effective treatment of gastrointestinal diseases including
inflammatory bowel disease is to develop an orally administered drug delivery system …

Protocells: Milestones and recent advances

I Gözen, ES Köksal, I Põldsalu, L Xue, K Spustova… - Small, 2022 - Wiley Online Library
The origin of life is still one of humankind's great mysteries. At the transition between
nonliving and living matter, protocells, initially featureless aggregates of abiotic matter, gain …

Biocatalytic cascades operating on macromolecular scaffolds and in confined environments

M Vázquez-González, C Wang, I Willner - Nature Catalysis, 2020 - nature.com
Biocatalytic cascades guide complex, efficient and selective intracellular transformations.
These unique features originate from the spatial organization of the biocatalysts in confined …

Enzyme-mediated nitric oxide production in vasoactive erythrocyte membrane-enclosed coacervate protocells

S Liu, Y Zhang, M Li, L Xiong, Z Zhang, X Yang… - Nature Chemistry, 2020 - nature.com
The design and construction of synthetic therapeutic protocells capable of establishing
cognate chemical communication channels with living cells is an important challenge for …

Phosphorylation-mediated RNA/peptide complex coacervation as a model for intracellular liquid organelles

WM Aumiller Jr, CD Keating - Nature chemistry, 2016 - nature.com
Biological cells are highly organized, with numerous subcellular compartments.
Phosphorylation has been hypothesized as a means to control the assembly/disassembly of …

Underwater contact adhesion and microarchitecture in polyelectrolyte complexes actuated by solvent exchange

Q Zhao, DW Lee, BK Ahn, S Seo, Y Kaufman… - Nature materials, 2016 - nature.com
Polyelectrolyte complexation is critical to the formation and properties of many biological
and polymeric materials, and is typically initiated by aqueous mixing followed by fluid–fluid …

Giant coacervate vesicles as an integrated approach to cytomimetic modeling

Y Zhang, Y Chen, X Yang, X He, M Li… - Journal of the …, 2021 - ACS Publications
Although giant unilamellar vesicles (GUVs) have been extensively studied as synthetic cell-
like microcompartments, their applicability as cytomimetic models is severely compromised …