Epigenetic regulatory mechanisms, including DNA methylation, histone modification,
chromatin remodeling, and microRNA expression, play critical roles in cell differentiation …

A large population of neural stem/precursor cells (NSCs) persists in the ventricular–
subventricular zone (V-SVZ) located in the walls of the lateral brain ventricles. V-SVZ NSCs …

Adult neurogenesis is a multistage process by which neurons are generated and integrated
into existing neuronal circuits. In the adult brain, neurogenesis is mainly localized in two …

Neurodevelopmental disorders (NDDs), including intellectual disability (ID) and autism
spectrum disorders (ASD), are a large group of disorders in which early insults during brain …

The birth of new neurons in the walls of the adult brain lateral ventricles has captured the
attention of many neuroscientists for over 2 decades, yielding key insights into the identity …

Seasonal neuroendocrine cycles that govern annual changes in reproductive activity,
energy metabolism and hair growth are almost ubiquitous in mammals that have evolved at …

The epigenetic mechanisms that enable lifelong neurogenesis from neural stem cells
(NSCs) in the adult mammalian brain are poorly understood. Here, we show that JMJD3, a …

The dynamic changes in chromatin conformation alter the organization and structure of the
genome and further regulate gene transcription. Basically, the chromatin structure is …

Spinal cord ependymal cells display neural stem cell properties in vitro and generate scar-
forming astrocytes and remyelinating oligodendrocytes after injury. We report that …

Disruption of chromatin structure due to epimutations is a leading genetic etiology of
neurodevelopmental disorders, collectively known as chromatinopathies. We show that …