Alkaloids as important scaffolds in therapeutic drugs for the treatments of cancer, tuberculosis, and smoking cessation

P Kittakoop, C Mahidol… - Current topics in medicinal …, 2014 - ingentaconnect.com
Alkaloid molecules can act, depending on a type of amine functionality present in alkalods,
as either hydrogenacceptor or hydrogen-donor for hydrogen bonding that is critically …

Oleanolic acid and its synthetic derivatives for the prevention and therapy of cancer: preclinical and clinical evidence

MK Shanmugam, X Dai, AP Kumar, BKH Tan, G Sethi… - Cancer letters, 2014 - Elsevier
Abstract Oleanolic acid (OA, 3β-hydroxyolean-12-en-28-oic acid) is a ubiquitous pentacyclic
multifunctional triterpenoid, widely found in several dietary and medicinal plants. Natural …

Oleanane-, ursane-, and quinone methide friedelane-type triterpenoid derivatives: Recent advances in cancer treatment

JAR Salvador, AS Leal, AS Valdeira… - European Journal of …, 2017 - Elsevier
Natural pentacyclic triterpenoids (PTs) have been often reported to exhibit a wide range of
biological activities. Among them, the anticancer and anti-inflammatory activities are the …

Bioactive properties of the main triterpenes found in olives, virgin olive oil, and leaves of Olea europaea

C Sánchez-Quesada, A López-Biedma… - Journal of agricultural …, 2013 - ACS Publications
Oleanolic acid, maslinic acid, uvaol, and erythrodiol are the main triterpenes present in
olives, olive tree leaves, and virgin olive oil. Their concentration in virgin olive oil depends …

Pentacyclic triterpenoids with nitrogen-containing heterocyclic moiety, privileged hybrids in anticancer drug discovery

V Khwaza, S Mlala, OO Oyedeji, BA Aderibigbe - Molecules, 2021 - mdpi.com
Pentacyclic triterpenoids are well-known phytochemicals with various biological activities
commonly found in plants as secondary metabolites. The wide range of biological activities …

Allyl‐Palladium‐Catalyzed Ketone Dehydrogenation Enables Telescoping with Enone α, β‐Vicinal Difunctionalization

Y Chen, D Huang, Y Zhao… - Angewandte Chemie …, 2017 - Wiley Online Library
The telescoping of allyl‐palladium catalyzed ketone dehydrogenation with organocuprate
conjugate addition chemistry allows for the introduction of aryl, heteroaryl, vinyl, acyl, methyl …

Improvement of ursolic and oleanolic acids' antitumor activity by complexation with hydrophilic cyclodextrins

C Oprean, M Mioc, E Csányi, R Ambrus, F Bojin… - Biomedicine & …, 2016 - Elsevier
Ursolic and oleanolic acids have been brought into the spotlight of research due to their
chemopreventive, anti-inflammatory and immunomodulatory properties. The most important …

Anti-cancer and anti-angiogenic properties of various natural pentacyclic tri-terpenoids and some of their chemical derivatives

EE Rufino-Palomares, A Perez-Jimenez… - Current Organic …, 2015 - benthamdirect.com
Pentacyclic triterpenes are natural substances, synthesized and present in variable amounts
in a large number of terrestrial and aquatic plants, which act not only as antioxidants and …

Multiple Active Compounds from Viscum album L. Synergistically Converge to Promote Apoptosis in Ewing Sarcoma

M Twardziok, S Kleinsimon, J Rolff, S Jäger, A Eggert… - PLoS …, 2016 - journals.plos.org
Ewing sarcoma is the second most common bone cancer in children and adolescents, with
poor prognosis and outcome in~ 70% of initial diagnoses and 10–15% of relapses …

Synthesis and anticancer activity of novel fluorinated asiatic acid derivatives

BMF Goncalves, JAR Salvador, S Marin… - European Journal of …, 2016 - Elsevier
A series of novel fluorinated Asiatic Acid (AA) derivatives were successfully synthesized,
tested for their antiproliferative activity against HeLa and HT-29 cell lines, and their structure …